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Autonomic nervous system mediates the hypotensive effects of aqueous and residual methanolic extracts of Syzygium polyanthum(Wight) Walp.var.polyanthum leaves in anaesthetized rats

Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptors....

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Bibliographic Details
Main Authors: Ismail, Azlini, Mohamed, M., Sulaiman, Siti Amrah, Wan Ahmad, W. A. N.
Format: Article
Language:English
Published: Hindawi Publishing Corporation 2013
Subjects:
RM Therapeutics. Pharmacology
RS Pharmacy and materia medica
Online Access:http://irep.iium.edu.my/48151/1/716532.pdf
http://irep.iium.edu.my/48151/
http://dx.doi.org/10.1155/2013/716532
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Summary:Syzygium polyanthum (Wight) Walp. var. polyanthum leaves are consumed as a traditional Malay treatment of hypertension. This study investigates hypotensive potential of aqueous (AESP) and residual methanolic (met-AESP) extracts of S. polyanthum leaves and possible involvement of autonomic receptors. AESP and met-AESP (20 to 100 mg/kg) were intravenously administered into anaesthetized Wistar-Kyoto (WKY) and spontaneously hypertensive (SHR) rats. Blood pressure and heart were monitored for 20 min. AESP and met-AESP induced significant dose-dependent hypotension, but only 100 mg/kg AESP caused mild bradycardia (

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