Analgesic synergism of gabapentin and carbamazepine in rat model of diabetic neuropathic pain

• Main Authors: Abdullah Al-Mahmood, Sinan Mohammed, Che Abdullah, Shahrin Tarmizi, Nik Ahmad, Nik Nur Fatnoon, Mohamed, Abdul Hadi, Abdul Razak, Tariq
• Format: Article
• Language: English; English; English
• Published: University of Benin 2016
• Subjects: RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/47664/1/Comparative_study_%28TJP.pdf; http://irep.iium.edu.my/47664/4/47664_Analgesic_synergism_of_gabapentin.pdf; http://irep.iium.edu.my/47664/7/47664-Analgesic%20synergism%20of%20gabapentin%20and%20carbamazepine%20in%20rat%20model%20of%20diabetic%20neuropathic%20pain_SCOPUS.pdf; http://irep.iium.edu.my/47664/; http://www.tjpr.org/admin/12389900798187/2016_15_6_11.pdf

Purpose: To evaluate synergy in the analgesic effects of a combination therapy of carbamazepine (CBZ) and gabapentin (GBP) in diabetic neuropathic pain. Methods: Neuropathic pain was produced in rats by a single intraperitoneal injection of streptozotocin (STZ) at 60 mg/kg. CBZ, GBP, and their co...