Development of generic gliclazide 60 mg modified release tablets using central composite design

• Main Authors: Elsayed, Tarek Mohamed Ali, Mandal, Uttam Kumar, Kasmuri, Abdul Razak
• Format: Article
• Language: English
• Published: College of Pharmacists of Buenos Aires Province, Argentina 2015
• Subjects: RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/44848/1/Latin_American_Journal_of_Pharmacy_34_8_page_1516.pdf; http://irep.iium.edu.my/44848/; http://www.latamjpharm.org/

A modified release gliclazide 60 mg tablet using Methocel® K100 Premium LV DC2 as a drug retaining polymer was prepared by direct compression. Central composite design was adopted for formulation optimization. The two independent formulation variables included the amount of Methocel® K100 LV DC2...