The pyrrolidine ring and its relation with the psychoactivity of mitragynine

• Main Authors: Mohd Ghazali, Masitah, Ridzwan, Irna Elina, Suhaimi, Maryam Saadah, Kasmuri, Abdul Razak, Hashim, Ridzwan, Aziz, Mohd Razif, Syd Mohmad Faudzi, Syed Mohd Syahmi
• Format: Conference or Workshop Item
• Language: English
• Published: 2015
• Subjects: QD Chemistry; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/44308/1/44308.pdf; http://irep.iium.edu.my/44308/

Mitragynine, the major alkaloid of Mitragyna speciosa has been widely studied for its anti-addictive properties. Similar to morphine, mitragynine mainly acts at mu-opioid receptor which is the main target to treat opioid dependency. Unfortunately, it is believed that the psychoactivity of mitragynin...