Lack of association between the MDM2 promoter polymorphism SNP309 and clinical outcome in chronic lymphocytic leukimia

• 主要な著者: Kaderi, Mohd Arifin, Mansouri, Mahmoud, Zainuddin, Norafiza, Cahill, Nicola, Gunnarsson, Rebeqa, Jansson, Mattias, Kimby, Eva, Aleskog, Anna, Lundin, Jeanette, Glimelius, Bengt, Melbye, Mads, Juliusson, Gunnar, Jesper Jurlander, Jesper, Rosenquist, Richard
• フォーマット: 論文
• 言語: English
• 出版事項: Elsevier 2010
• 主題: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• オンライン･アクセス: http://irep.iium.edu.my/4408/1/Paper_III_Norafiza_Zainuddin.pdf; http://irep.iium.edu.my/4408/; http://www.sciencedirect.com/science/article/pii/S0145212609002835

The 309T>G polymorphism in the promoter region of the MDM2 gene, known as SNP309, has recently been suggested as an unfavorable prognostic marker in chronic lymphocytic leukemia (CLL) although this has been questioned. To investigate this further, we analyzed the MDM2 SNP309 genotypes in 418 CLL...