Lack of association between the MDM2 promoter polymorphism SNP309 and clinical outcome in chronic lymphocytic leukimia

• Main Authors: Kaderi, Mohd Arifin, Mansouri, Mahmoud, Zainuddin, Norafiza, Cahill, Nicola, Gunnarsson, Rebeqa, Jansson, Mattias, Kimby, Eva, Aleskog, Anna, Lundin, Jeanette, Glimelius, Bengt, Melbye, Mads, Juliusson, Gunnar, Jesper Jurlander, Jesper, Rosenquist, Richard
• Format: Article
• Language: English
• Published: Elsevier 2010
• Subjects: RC0254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://irep.iium.edu.my/4408/1/Paper_III_Norafiza_Zainuddin.pdf; http://irep.iium.edu.my/4408/; http://www.sciencedirect.com/science/article/pii/S0145212609002835

The 309T>G polymorphism in the promoter region of the MDM2 gene, known as SNP309, has recently been suggested as an unfavorable prognostic marker in chronic lymphocytic leukemia (CLL) although this has been questioned. To investigate this further, we analyzed the MDM2 SNP309 genotypes in 418 CLL...