Potential antifilarial activity of the fruit, leaf and stem extracts of Melia azedarach Linn. on cattle filarial parasite Setaria cervi in vitro
The effect of aqueous and alcoholic extracts of the fruit, leaf and stem of Melia azedarach Linn.(Meliaceae) on the spontaneous movements of both the whole worm and the nerve-muscle(n.m.) preparation of Setaria (S.) cervi and on the survival of microfilariae in vitro was studied.Alcoholic extracts o...
Saved in:
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Springer, Springer Korea Limited, Seoul, Korea (Rep.).
2006
|
Subjects: | |
Online Access: | http://irep.iium.edu.my/41003/1/Potential_antifilarial_activity_of_the_fruit%2C_leaf_and_stem_extract_of_Melia_azedarach_Linn._on_cattle_filarial_parasite_Setaria_cervi_in_vitro.pdf http://irep.iium.edu.my/41003/ http://opem.or.kr/bbs/board.php?bo_table=m02_09&wr_id=16&device=mobile |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.iium.irep.41003 |
---|---|
record_format |
dspace |
spelling |
my.iium.irep.410032015-03-11T01:34:41Z http://irep.iium.edu.my/41003/ Potential antifilarial activity of the fruit, leaf and stem extracts of Melia azedarach Linn. on cattle filarial parasite Setaria cervi in vitro Ahmed, Qamar Uddin Zaidi, SMKR Kaleem, Mohammed Khan, N. U. Singhal, K. C. QL Zoology The effect of aqueous and alcoholic extracts of the fruit, leaf and stem of Melia azedarach Linn.(Meliaceae) on the spontaneous movements of both the whole worm and the nerve-muscle(n.m.) preparation of Setaria (S.) cervi and on the survival of microfilariae in vitro was studied.Alcoholic extracts of fruit, leaf and stem caused inhibition of the spontaneous movements of thewhole worm and the n.m. preparation of S. cervi, while only aqueous extract of fruit causedinhibition of the spontaneous movements of the whole worm and the n.m. preparation of S.cervi. The initial stimulatory effect was not observed by the aqueous and alcoholic extracts offruit on n.m. preparation. The concentrations required to inhibit the movements of the wholeworm and n.m. preparation for alcoholic extracts of fruit, leaf and stem were 250, 40 µg/ml;280, 40 µg/ml and 270, 25 µg/ml respectively, whereas an aqueous extract of fruit causedinhibition of whole worm and n.m. preparation at 200 µg/ml and 40 µg/ml respectively.Alcoholic extracts of the fruit, leaf and stem and aqueous extract of the fruit of M. azedarachcaused concentration related inhibition on the survival of microfilariae (m.f.) of S. cervi. TheLC50 and LC90 as observed after 6 h were found to be 5, 15, 10, 20 ng/ml and 10, 25, 20 and 35ng/ml, respectively. This work was conducted in view of the exploration of potentialantifilarial herbal drug. Springer, Springer Korea Limited, Seoul, Korea (Rep.). 2006-06 Article REM application/pdf en http://irep.iium.edu.my/41003/1/Potential_antifilarial_activity_of_the_fruit%2C_leaf_and_stem_extract_of_Melia_azedarach_Linn._on_cattle_filarial_parasite_Setaria_cervi_in_vitro.pdf Ahmed, Qamar Uddin and Zaidi, SMKR and Kaleem, Mohammed and Khan, N. U. and Singhal, K. C. (2006) Potential antifilarial activity of the fruit, leaf and stem extracts of Melia azedarach Linn. on cattle filarial parasite Setaria cervi in vitro. Oriental Pharmacy and Experimental Medicine, 6 (2). pp. 144-156. ISSN 1598-2386 http://opem.or.kr/bbs/board.php?bo_table=m02_09&wr_id=16&device=mobile 10.3742/OPEM.2006.6.2.144. |
institution |
Universiti Islam Antarabangsa Malaysia |
building |
IIUM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
International Islamic University Malaysia |
content_source |
IIUM Repository (IREP) |
url_provider |
http://irep.iium.edu.my/ |
language |
English |
topic |
QL Zoology |
spellingShingle |
QL Zoology Ahmed, Qamar Uddin Zaidi, SMKR Kaleem, Mohammed Khan, N. U. Singhal, K. C. Potential antifilarial activity of the fruit, leaf and stem extracts of Melia azedarach Linn. on cattle filarial parasite Setaria cervi in vitro |
description |
The effect of aqueous and alcoholic extracts of the fruit, leaf and stem of Melia azedarach Linn.(Meliaceae) on the spontaneous movements of both the whole worm and the nerve-muscle(n.m.) preparation of Setaria (S.) cervi and on the survival of microfilariae in vitro was studied.Alcoholic extracts of fruit, leaf and stem caused inhibition of the spontaneous movements of thewhole worm and the n.m. preparation of S. cervi, while only aqueous extract of fruit causedinhibition of the spontaneous movements of the whole worm and the n.m. preparation of S.cervi. The initial stimulatory effect was not observed by the aqueous and alcoholic extracts offruit on n.m. preparation. The concentrations required to inhibit the movements of the wholeworm and n.m. preparation for alcoholic extracts of fruit, leaf and stem were 250, 40 µg/ml;280, 40 µg/ml and 270, 25 µg/ml respectively, whereas an aqueous extract of fruit causedinhibition of whole worm and n.m. preparation at 200 µg/ml and 40 µg/ml respectively.Alcoholic extracts of the fruit, leaf and stem and aqueous extract of the fruit of M. azedarachcaused concentration related inhibition on the survival of microfilariae (m.f.) of S. cervi. TheLC50 and LC90 as observed after 6 h were found to be 5, 15, 10, 20 ng/ml and 10, 25, 20 and 35ng/ml, respectively. This work was conducted in view of the exploration of potentialantifilarial herbal drug. |
format |
Article |
author |
Ahmed, Qamar Uddin Zaidi, SMKR Kaleem, Mohammed Khan, N. U. Singhal, K. C. |
author_facet |
Ahmed, Qamar Uddin Zaidi, SMKR Kaleem, Mohammed Khan, N. U. Singhal, K. C. |
author_sort |
Ahmed, Qamar Uddin |
title |
Potential antifilarial activity of the fruit, leaf and stem extracts of Melia azedarach Linn. on cattle filarial parasite Setaria cervi in vitro |
title_short |
Potential antifilarial activity of the fruit, leaf and stem extracts of Melia azedarach Linn. on cattle filarial parasite Setaria cervi in vitro |
title_full |
Potential antifilarial activity of the fruit, leaf and stem extracts of Melia azedarach Linn. on cattle filarial parasite Setaria cervi in vitro |
title_fullStr |
Potential antifilarial activity of the fruit, leaf and stem extracts of Melia azedarach Linn. on cattle filarial parasite Setaria cervi in vitro |
title_full_unstemmed |
Potential antifilarial activity of the fruit, leaf and stem extracts of Melia azedarach Linn. on cattle filarial parasite Setaria cervi in vitro |
title_sort |
potential antifilarial activity of the fruit, leaf and stem extracts of melia azedarach linn. on cattle filarial parasite setaria cervi in vitro |
publisher |
Springer, Springer Korea Limited, Seoul, Korea (Rep.). |
publishDate |
2006 |
url |
http://irep.iium.edu.my/41003/1/Potential_antifilarial_activity_of_the_fruit%2C_leaf_and_stem_extract_of_Melia_azedarach_Linn._on_cattle_filarial_parasite_Setaria_cervi_in_vitro.pdf http://irep.iium.edu.my/41003/ http://opem.or.kr/bbs/board.php?bo_table=m02_09&wr_id=16&device=mobile |
_version_ |
1643611929349980160 |
score |
13.160551 |