Paraoxonase-1 (PON1): bridging the organophosphate exposure to atherosclerosis

• Main Authors: Abdullah, Nor Zamzila, A.Talib, Norlelawati, Buyong, Zunariah, Ku Zaifah, Norsidah, Samsuddin, Niza, Mohamed, Abdul Hadi, Abdullah, Nasuruddin, Mat Zainone, Zamzuria, Abdul Razak, Redzuan Nul Hakim
• Format: Article
• Language: English
• Published: Malaysian Society of Pathologists 2014
• Subjects: RB Pathology
• Online Access: http://irep.iium.edu.my/40185/1/IC_Palm_Nor_Zamzila_Abdullah_2014_%28selected_page%29.pdf; http://irep.iium.edu.my/40185/

Introduction: Organophosphate (OP) is hydrolyzed by paraoxonase (PON1), an antioxidant enzyme that prevent atherosclerosis by inhibiting oxidative modification of low density lipoprotein (LDL). Low PON1 activities have been observed among individuals chronically exposed to OP while their decreased a...