Microscopic diffusion properties of fixed breast tissue: preliminary findings
Purpose: To investigate the microscopic diffusion properties of formalin-fixed breast tissue. Methods: Diffusion microimaging was performed at 16.4T with 40-mm isotropic voxels on two normal and two cancer tissue samples from four patients. Results were correlated with histology of the samples....
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Main Authors: | , , , , , , |
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Format: | Article |
Language: | English English |
Published: |
Wiley
2014
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Subjects: | |
Online Access: | http://irep.iium.edu.my/40078/1/MRM-_Decision_on_Manuscript_-_Narina_Norddin.pdf http://irep.iium.edu.my/40078/2/Norddin_et_al_2014_.pdf http://irep.iium.edu.my/40078/ http://onlinelibrary.wiley.com/doi/10.1002/mrm.25555/abstract |
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Summary: | Purpose: To investigate the microscopic diffusion properties
of formalin-fixed breast tissue.
Methods: Diffusion microimaging was performed at 16.4T with
40-mm isotropic voxels on two normal and two cancer tissue
samples from four patients. Results were correlated with histology
of the samples.
Results: Diffusion-weighted images and mean diffusivity maps
demonstrated distinct diffusivity differences between breast
tissue components. Mean diffusivity (MD) in normal tissue was
0.5960.24 mm2/ms for gland lobule (voxels containing epithelium
and intralobular stroma) and 1.2360.34 mm2/ms for interlobular
fibrous stroma. In the cancer samples,
MD¼0.4560.23 mm2/ms for invasive ductal carcinoma (voxels
contain epithelium and intralobular stroma) and 0.6160.35
mm2/ms for ductal carcinoma in situ. There were significant
MD differences between all tissue components (P<0.005),
except between gland lobule and ductal carcinoma in situ
(P¼0.71). The low diffusivity of epithelium-rich cancer tissue
and of normal epithelium relative to its supporting fibrous
stroma was similar to that reported for prostate tissue and the
esophageal wall.
Conclusion: Diffusion microimaging demonstrates distinct diffusivity
differences between breast tissue glandular structures.
Low diffusivity may be a distinctive feature of mammalian epithelia. |
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