Pathway analysis of genes affected in MCF-7 breast cancer cells treated with recombinant bromelain
The contributing molecular pathways underlying the pathogenesis of breast cancer need to be better characterized. The goal of the present study is to understand the probable molecular mechanism and the associated pathway related to recombinant bromelain treatment on MCF-7 breast cancer cells. Wit...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Journal of Pure and Applied Microbiology
2014
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/38444/1/May_Nour_JPAM.pdf http://irep.iium.edu.my/38444/3/38444_Pathway%20analysis%20of%20genes%20affected%20in.SCOPUS.pdf http://irep.iium.edu.my/38444/ http://www.microbiologyjournal.org/ |
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| Summary: | The contributing molecular pathways underlying the pathogenesis of breast
cancer need to be better characterized. The goal of the present study is to understand the
probable molecular mechanism and the associated pathway related to recombinant
bromelain treatment on MCF-7 breast cancer cells. Within 1102 known genes differentially
expressed to a significant degree (p<0.001) set, 34 genes were significantly changed between
treated cells and the control cells with cutoff fold change more than 2. These genes are
LYRM2, TUBB2C, LRRFIP1, HMGN2, HMGN2, GLTSCR2, RN28S1, HIST2H4B, HIST2H4A,
PA2G4, ACTB, C1orf152, RPS3A, C12orf51, RAP1B, FLJ16171, CCDC59, MGEA5, KIFAP3,
GPBP1, KLHDC2, TBPL1, STK38L, RIOK3, CLK4 SNORD46, C7orf60, BTG1, TMEM59,
ARID4A, C6orf62, FRG1, DEFB109P1B and RBMS1. With this exploratory study using
Ingenuity Pathway Analysis IPA, we aim to identify the overlapping pathways associated
with recombinant bromelain treatment and its anti-cancer mechanisms in MCF-7 breast
cancer cells. The pathways identification has been shown to be associated with recombinant
bromelain function on cell cycle, cancer, cell death & survival, cellular development,
tumor morphology, cellular growth and proliferation. This finding will enhance the
power of In-vitro breast cancer study and lead to better understanding |
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