Subchondral bone plate thickening precedes chondrocyte apoptosis and cartilage degradation in spontaneous animal models of osteoarthritis

• Main Authors: Zamli, Zaitunnatakhin, Brown, Kate Robson, Tarlton, John F., Adams, Mike A., Torlot, Georgina E., Cartwright, Charlie, Cook, William A., Vassilevskaja, Kristiina, Sharif, Mohammed
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation 2014
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/37057/1/Subchondral_Bone_Plate_Thickening_Precedes_Chondrocyte_Apoptosis_and_Cartilage_Degradation_in_Spontaneous_Animal_Models_of_Osteoarthritis.pdf; http://irep.iium.edu.my/37057/; http://dx.doi.org/10.1155/2014/606870

Osteoarthritis (OA) is the most common joint disorder characterised by bone remodelling and cartilage degradation and associated with chondrocyte apoptosis. These processes were investigated at 10, 16, 24, and 30 weeks in Dunkin Hartley (DH) and Bristol Strain 2 (BS2) guinea pigs that develop OA spo...