Perinatal programming of hypertension on exposure to high and low sodium chloride diet during pregnancy and lactation in Sprague-Dawley rats

• Main Authors: Aminuddin, Niferiti, Abdul Razak, Tariq, Azzubaidi, Marwan Saad, Tin, Myo Han, Mohd Noor, Noriah
• Format: Conference or Workshop Item
• Language: English
• Published: 2014
• Subjects: QP Physiology; R Medicine (General); RG Gynecology and obstetrics
• Online Access: http://irep.iium.edu.my/34805/2/PERINATAL_PROGRAMMING_2014_MSH.pdf; http://irep.iium.edu.my/34805/; http://www.msh.my/article.php?aid=367

Background: Adverse conditions in utero may lead to hypertension during in later life, however inconsistency of the result has been reported. Objective: This experiment aims at studying the effects of high and low maternal dietary sodium on their offspring’s blood pressure at 4 and 8 weeks. Materials and methods: Normotensive female rats were subjected to timed pregnancy. Pregnant rats were randomly divided into three groups and were fed either low-sodium diet (LSD) (0.145%NaCl) (n=10), normal-sodium diet (NSD) (1.0%NaCl) (n=10) or high-sodium diet (HSD) (3.0%NaCl)(n=10) during pregnancy and 4 weeks of lactation. The offsprings were weaned at 4 weeks old. Thereafter, all the three groups were fed with normal-sodium diet (1.0%NaCl) for another 4 weeks. Results: At 4 weeks old, the offsprings of HSD dams have significantly higher systolic blood pressure(SBP) compared to NSD group respectively (119.44mmHg ±1.8 vs 103.65mmHg ±0.92). There were no differences in the offspring’s SBP between NSD and LSD dams at 4 weeks old. Nevertheless, at 8 weeks old, the offspring’s of LSD dams have significantly higher SBP as compared to NSD dams (130.13±1.45mmHg vs 120.26mmHg±1.09). Similarly, at 8 weeks old, the offspring of HSD dams have significantly higher SBP as compared to NSD dams 131.06±1.49mmHg vs 120.26mmHg±1.09). The offspring’s heart rate, average food intake and body weight were similar between all the three groups at 4 and 8 weeks. Conclusions: This suggests that the offspring of both HSD and LSD have greater propensity to develop higher blood pressure and it is pertinent to consider optimum dietary sodium consumption during. pregnancy.