A central bioactive region of LTBP-2 stimulates the expression of TGF-β1 in fibroblasts via akt and p38 signalling pathways

• Main Authors: Sideek, Mohamed Arshad, Smith, Joshua J., Menz, Clementine, Adams, Julian R. J., Cowin, Allison J., Gibson, Mark A.
• Format: Article
• Language: English; English
• Published: Multidisciplinary Digital Publishing Institute (MDPI) 2017
• Subjects: QD Chemistry; R Medicine (General); RA0421 Public health. Hygiene. Preventive Medicine
• Online Access: http://irep.iium.edu.my/31820/1/31820_A%20Central%20Bioactive%20Region%20of%20LTBP-2%20Stimulates.pdf; http://irep.iium.edu.my/31820/2/31820_A%20Central%20Bioactive%20Region%20of%20LTBP-2%20Stimulates_scopus.pdf; http://irep.iium.edu.my/31820/; http://www.mdpi.com/1422-0067/18/10/2114

Latent transforming growth factor-β-1 binding protein-2 (LTBP-2) belongs to the LTBP-fibrillin superfamily of extracellular proteins. Unlike other LTBPs, LTBP-2 does not covalently bind transforming growth factor-β1 (TGF-β1) but appears to be implicated in the regulation of TGF-β1 bioactivity, altho...