An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract

Inflammation is the complex biological response of vascular tissue to harmful stimuli such as pathogens, damaged cells, or irritants. In the present investigation an attempt was made to screen the anti-inflammatory activity of Basellaalba leaf. From this study, it can be concluded that, Basellaalba...

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Main Authors: Abdul Kalam, Azad, Wan Sulaiman, Wan Mohd. Azizi, Z. M., Babar, Labu, Zubair Khalid, Zabin, S.
Format: Article
Language:English
Published: International Digital Organization for Scientific Information (IDOSI) 2013
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Online Access:http://irep.iium.edu.my/30539/1/Azad_MEJSR-Bsella_alba.pdf
http://irep.iium.edu.my/30539/
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spelling my.iium.irep.305392013-07-01T01:55:11Z http://irep.iium.edu.my/30539/ An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract Abdul Kalam, Azad Wan Sulaiman, Wan Mohd. Azizi Z. M., Babar Labu, Zubair Khalid Zabin, S. QD Chemistry QR180 Immunology RS Pharmacy and materia medica RV Botanic, Thomsonian, and eclectic medicine Inflammation is the complex biological response of vascular tissue to harmful stimuli such as pathogens, damaged cells, or irritants. In the present investigation an attempt was made to screen the anti-inflammatory activity of Basellaalba leaf. From this study, it can be concluded that, Basellaalba possesses a good anti-inflammatory activity. In the cotton pellet induced inflammation and In the carrageenan induced inflammation the animals treated with the plant extract have been shown a significant activity at 500 mg/kg dose (p<0.001) which was comparable with the standard drug. In view of the percentage inhibition also the plant was studied, in which the plant extract was found effective. The antibacterial activity was carried out using different dilutions of methanolic extract against gram positive strains (Staphylococcus aureus, Micrococcus luteus, Bacillus subtilus) and gram negative ones (Pseudomonas aeruginosa) by the cup-plate assay method and minimum inhibitory concentrations (MICs). The different concentrations of extract showed moderate activity against Pseudomonas aeruginosa, Bacillus subtiliswhile weak response against Staphylococcus aureus, Micrococcus luteus and Escherichiacoli. The minimum inhibitory concentration of methanolic extract was 6.25μg/ml against Staphylococcus aureus, Micrococcus luteus, Pseudomonas aeruginosa and Bacillussubtilus and 12.5 μg/ml against Escherichia coli. The overall result of this study indicates that the methanolic extract of Basellaalba have interesting anti-inflammatory and antibacterial properties. International Digital Organization for Scientific Information (IDOSI) 2013 Article REM application/pdf en http://irep.iium.edu.my/30539/1/Azad_MEJSR-Bsella_alba.pdf Abdul Kalam, Azad and Wan Sulaiman, Wan Mohd. Azizi and Z. M., Babar and Labu, Zubair Khalid and Zabin, S. (2013) An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract. Middle-East Journal of Scientific Research, 14 (5). pp. 650-655. ISSN 1990-9233 http://www.idosi.org/mejsr/mejsr.htm 10.5829/idosi.mejsr.2013.14.5.71225
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QD Chemistry
QR180 Immunology
RS Pharmacy and materia medica
RV Botanic, Thomsonian, and eclectic medicine
spellingShingle QD Chemistry
QR180 Immunology
RS Pharmacy and materia medica
RV Botanic, Thomsonian, and eclectic medicine
Abdul Kalam, Azad
Wan Sulaiman, Wan Mohd. Azizi
Z. M., Babar
Labu, Zubair Khalid
Zabin, S.
An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
description Inflammation is the complex biological response of vascular tissue to harmful stimuli such as pathogens, damaged cells, or irritants. In the present investigation an attempt was made to screen the anti-inflammatory activity of Basellaalba leaf. From this study, it can be concluded that, Basellaalba possesses a good anti-inflammatory activity. In the cotton pellet induced inflammation and In the carrageenan induced inflammation the animals treated with the plant extract have been shown a significant activity at 500 mg/kg dose (p<0.001) which was comparable with the standard drug. In view of the percentage inhibition also the plant was studied, in which the plant extract was found effective. The antibacterial activity was carried out using different dilutions of methanolic extract against gram positive strains (Staphylococcus aureus, Micrococcus luteus, Bacillus subtilus) and gram negative ones (Pseudomonas aeruginosa) by the cup-plate assay method and minimum inhibitory concentrations (MICs). The different concentrations of extract showed moderate activity against Pseudomonas aeruginosa, Bacillus subtiliswhile weak response against Staphylococcus aureus, Micrococcus luteus and Escherichiacoli. The minimum inhibitory concentration of methanolic extract was 6.25μg/ml against Staphylococcus aureus, Micrococcus luteus, Pseudomonas aeruginosa and Bacillussubtilus and 12.5 μg/ml against Escherichia coli. The overall result of this study indicates that the methanolic extract of Basellaalba have interesting anti-inflammatory and antibacterial properties.
format Article
author Abdul Kalam, Azad
Wan Sulaiman, Wan Mohd. Azizi
Z. M., Babar
Labu, Zubair Khalid
Zabin, S.
author_facet Abdul Kalam, Azad
Wan Sulaiman, Wan Mohd. Azizi
Z. M., Babar
Labu, Zubair Khalid
Zabin, S.
author_sort Abdul Kalam, Azad
title An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
title_short An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
title_full An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
title_fullStr An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
title_full_unstemmed An overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
title_sort overview on phytochemical, anti-inflammatory and anti-bacterial activity of basella alba leaves extract
publisher International Digital Organization for Scientific Information (IDOSI)
publishDate 2013
url http://irep.iium.edu.my/30539/1/Azad_MEJSR-Bsella_alba.pdf
http://irep.iium.edu.my/30539/
http://www.idosi.org/mejsr/mejsr.htm
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score 13.18916