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Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate

A new tridentate nitrogen-sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallogr...

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Main Authors: Ravoof, Thahira Begum, Crouse, Karen Anne, Tahir, Mohamed Ibrahim Mohamed, Rosli, Rozita, Watkin, David J., How, Fiona Ni Foong
格式: Article
语言:English
出版: SpringerLink 2011
主题:
QD Chemistry
在线阅读:http://irep.iium.edu.my/300/1/jocc_paper.pdf
http://irep.iium.edu.my/300/
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spelling my.iium.irep.3002012-02-29T06:50:34Z http://irep.iium.edu.my/300/ Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate Ravoof, Thahira Begum Crouse, Karen Anne Tahir, Mohamed Ibrahim Mohamed Rosli, Rozita Watkin, David J. How, Fiona Ni Foong QD Chemistry A new tridentate nitrogen-sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) Å, b = 9.3832 (2) Å, c = 18.0352 (4) Å, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor). SpringerLink 2011-04 Article REM application/pdf en http://irep.iium.edu.my/300/1/jocc_paper.pdf Ravoof, Thahira Begum and Crouse, Karen Anne and Tahir, Mohamed Ibrahim Mohamed and Rosli, Rozita and Watkin, David J. and How, Fiona Ni Foong (2011) Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate. Journal of Chemical Crystallography, 41 (4). pp. 491-495. ISSN 1074-1542 10.1007/s10870-010-9907-3
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic QD Chemistry
spellingShingle QD Chemistry
Ravoof, Thahira Begum
Crouse, Karen Anne
Tahir, Mohamed Ibrahim Mohamed
Rosli, Rozita
Watkin, David J.
How, Fiona Ni Foong
Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
description A new tridentate nitrogen-sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) Å, b = 9.3832 (2) Å, c = 18.0352 (4) Å, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor).
format Article
author Ravoof, Thahira Begum
Crouse, Karen Anne
Tahir, Mohamed Ibrahim Mohamed
Rosli, Rozita
Watkin, David J.
How, Fiona Ni Foong
author_facet Ravoof, Thahira Begum
Crouse, Karen Anne
Tahir, Mohamed Ibrahim Mohamed
Rosli, Rozita
Watkin, David J.
How, Fiona Ni Foong
author_sort Ravoof, Thahira Begum
title Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
title_short Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
title_full Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
title_fullStr Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
title_full_unstemmed Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
title_sort synthesis, characterisation and biological activities of 2-methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate
publisher SpringerLink
publishDate 2011
url http://irep.iium.edu.my/300/1/jocc_paper.pdf
http://irep.iium.edu.my/300/
_version_ 1643604594003017728
score 13.149126

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