Synthesis, characterisation and biological activities of 2-Methylbenzyl 2-(dipyridin-2-yl methylene)hydrazinecarbodithioate

• Main Authors: Ravoof, Thahira Begum, Crouse, Karen Anne, Tahir, Mohamed Ibrahim Mohamed, Rosli, Rozita, Watkin, David J., How, Fiona Ni Foong
• Format: Article
• Language: English
• Published: SpringerLink 2011
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/300/1/jocc_paper.pdf; http://irep.iium.edu.my/300/

A new tridentate nitrogen-sulphur Schiff base has been synthesised from the condensation of di-2-pyridylketone and a novel dithiocarbazate, S-2-methylbenzyl-dithiocarbazate (S2MBDTC). The Schiff base was characterized using various physico-chemical and spectroscopic techniques. The X-ray crystallographic analysis of the Schiff base is reported. The Schiff base crystallized in a monoclinic system with a space group of P 21/n, with crystal cell parameters a = 10.8128 (2) Å, b = 9.3832 (2) Å, c = 18.0352 (4) Å, β = 97.1311 (9)°. The Schiff base was found to be inactive against selected microbes and two breast cancer cell lines (MCF-7 = Human breast cancer cell line with positive estrogen receptor and MDA-MB-231 = Human breast cancer cell line with negative estrogen receptor).