TP53 mutations predict for poor survival in de novo diffuse large B-cell lymphoma of germinal center subtype

• Main Authors: Zainuddin, Norafiza, Berglund, Mattias, Wanders, Alkwin, Ren, Zhi-Ping, Amini, Rose-Marie, Lindell, Monica, Kanduri, Meena, Roos, Göran, Rosenquist, Richard, Enblad, Gunilla
• Format: Article
• Language: English
• Published: Elsevier Limited 2008
• Subjects: RC254 Neoplasms. Tumors. Oncology (including Cancer)
• Online Access: http://irep.iium.edu.my/29949/1/Preview_of_%E2%80%9CUntitled_Document%E2%80%9D_tp53.pdf; http://irep.iium.edu.my/29949/; http://www.lrjournal.com/article/S0145-2126(10)00428-5/abstract

Presence of TP53 mutations has been associated with poor prognosis in diffuse large B-cell lymphoma (DLBCL), although this has remained controversial. The TP53 codon 72 polymorphism has shown negative impact on cancer survival, but this has not been analyzed in DLBCL. Furthermore, the MDM2 SNP309...