Correlation of serum insulin like growth factor-I with retinopathy in Malaysian pregnant diabetics
AIM: To study the association of serum insulin-like growth factor-I (IGF-I) with diabetic retinopathy. ·METHODS: Serum IGF-1 levels were measured in 25 pregnant diabetic patients and 25 pregnant non-diabetic patients who were matched for age, ethnicity, parity and period of gestation. Fundus ex...
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| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Zhonghua Yixuehui Xian Fenhui
2011
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/20734/1/Correlation_of_serum_insulin_like_growth_factor_-I_with_retinopathy_in_malaysian_pregnant_diabetics.pdf http://irep.iium.edu.my/20734/ |
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| Summary: | AIM: To study the association of serum insulin-like growth
factor-I (IGF-I) with diabetic retinopathy.
·METHODS: Serum IGF-1 levels were measured in 25
pregnant diabetic patients and 25 pregnant non-diabetic
patients who were matched for age, ethnicity, parity and
period of gestation. Fundus examination was performed in
both groups at 28, 32 and 36 weeks of gestation.
·RESULTS: The serum IGF-I level was significantly elevated
in pregnant diabetics compared to pregnant non-diabetics
(366± 199滋g/L 184± 89滋g/L, ( =0.0001) at 24 weeks,
535± 251滋g/L 356± 89滋g/L, ( =0.007) at 32 weeks and
404± 166滋g/L 264± 113滋g/L, ( =0.003) at 36 weeks of
gestation). The pregnant diabetics with established diabetes
had significantly higher IGF-1 level than gestational diabetes at 28, 32 and 36 weeks of gestation. The serum IGF-I level in pregnant diabetics with retinopathy was significantly higher than in those without retinopathy at all periods of gestation. |
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