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Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines

This study was designed to determine antiproliferative properties of curcusone B from the stem bark of Jatropha curcas on cell lines K562 (chronic myelogeneous leukemia), and H1299 (human non-small cell lung carcinoma). Cells were cultured in the presence of curcusone B at various concentrations...

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Main Authors: Sahidin,, Nakazibwe, Sauba, Taher, Muhammad, Kumar Saxena, Anil, Arief Ichwan, Solachuddin Jauhari, Ardiyansyah,
Format: Article
Language:English
Published: INSI Publications 2011
Subjects:
RM Therapeutics. Pharmacology
Online Access:http://irep.iium.edu.my/20337/1/antiproliferative_activity_of_curcusone_B_from_jatropha.pdf
http://irep.iium.edu.my/20337/
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spelling my.iium.irep.203372014-03-11T00:29:38Z http://irep.iium.edu.my/20337/ Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines Sahidin, Nakazibwe, Sauba Taher, Muhammad Kumar Saxena, Anil Arief Ichwan, Solachuddin Jauhari Ardiyansyah, RM Therapeutics. Pharmacology This study was designed to determine antiproliferative properties of curcusone B from the stem bark of Jatropha curcas on cell lines K562 (chronic myelogeneous leukemia), and H1299 (human non-small cell lung carcinoma). Cells were cultured in the presence of curcusone B at various concentrations and the percentage of cell viability was evaluated by trypan blue exclusion method and MTT assay. Curcusone B showed significant dose-dependent inhibition of cell proliferation of K562 and H1299 cell lines with an IC50 of 6 μg/mL and 15.0 μg/mL, respectively. The findings suggested that the curcusone B had strong antiproliferation which was dose dependent and may have potential as an anticancer agent. INSI Publications 2011 Article REM application/pdf en http://irep.iium.edu.my/20337/1/antiproliferative_activity_of_curcusone_B_from_jatropha.pdf Sahidin, and Nakazibwe, Sauba and Taher, Muhammad and Kumar Saxena, Anil and Arief Ichwan, Solachuddin Jauhari and Ardiyansyah, (2011) Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines. Australian Journal of Basic and Applied Sciences, 5 (8). pp. 47-51. ISSN 1991-8178
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
topic RM Therapeutics. Pharmacology
spellingShingle RM Therapeutics. Pharmacology
Sahidin,
Nakazibwe, Sauba
Taher, Muhammad
Kumar Saxena, Anil
Arief Ichwan, Solachuddin Jauhari
Ardiyansyah,
Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
description This study was designed to determine antiproliferative properties of curcusone B from the stem bark of Jatropha curcas on cell lines K562 (chronic myelogeneous leukemia), and H1299 (human non-small cell lung carcinoma). Cells were cultured in the presence of curcusone B at various concentrations and the percentage of cell viability was evaluated by trypan blue exclusion method and MTT assay. Curcusone B showed significant dose-dependent inhibition of cell proliferation of K562 and H1299 cell lines with an IC50 of 6 μg/mL and 15.0 μg/mL, respectively. The findings suggested that the curcusone B had strong antiproliferation which was dose dependent and may have potential as an anticancer agent.
format Article
author Sahidin,
Nakazibwe, Sauba
Taher, Muhammad
Kumar Saxena, Anil
Arief Ichwan, Solachuddin Jauhari
Ardiyansyah,
author_facet Sahidin,
Nakazibwe, Sauba
Taher, Muhammad
Kumar Saxena, Anil
Arief Ichwan, Solachuddin Jauhari
Ardiyansyah,
author_sort Sahidin,
title Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
title_short Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
title_full Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
title_fullStr Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
title_full_unstemmed Antiproliferative activity of Curcusone B from Jatropha Curcas on human cancer cell lines
title_sort antiproliferative activity of curcusone b from jatropha curcas on human cancer cell lines
publisher INSI Publications
publishDate 2011
url http://irep.iium.edu.my/20337/1/antiproliferative_activity_of_curcusone_B_from_jatropha.pdf
http://irep.iium.edu.my/20337/
_version_ 1643607881102131200
score 13.18916

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