Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats
Oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation and antioxidant properties. This study evaluated the catechin-rich OPLE antioxidant, antihypertensive, and cardiovascular effects in normal and nitric oxide (NO)–deficient hypertensive rats. OPLE was administered...
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2011
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my.iium.irep.154782013-06-26T01:31:46Z http://irep.iium.edu.my/15478/ Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats Md. Jaffri, Juliana Mohamed, Suhaila Rohimi, Nordanial Ahmad, Intan Natasya Mohamed Mustapha, Noordin Manap, Mohd Yazid RM695 Physical medicine. Physical therapy Oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation and antioxidant properties. This study evaluated the catechin-rich OPLE antioxidant, antihypertensive, and cardiovascular effects in normal and nitric oxide (NO)–deficient hypertensive rats. OPLE was administered orally (500 mg=kg of body weight=day) to normotensive Wistar rats and Nx-nitro-l-arginine methyl ester (l-NAME)-induced NO-deficient hypertensive rats. OPLE significantly (P < .05) attenuated blood pressure increases, increased serum NO, reduced lipid peroxidation, and showed antioxidant effects in NO-deficient hypertensive rats. OPLE decreased the coronary arteriole wall-to-lumen ratio to near normal values under NO deficiency. Although OPLE showed good antihypertensive and antioxidant effects under NO deficiency, it was not hypotensive to normal rats and produced no chronic cardiovascular toxicity in any of the rats throughout the 12-week study. This is the first report on the in vivo antihypertensive properties of green tea catechins extracted from an alternative source, namely, oil palm leaf, for use as a medicinal food for hypertension and cardiovascular ailments. Mary Ann Liebert Inc. 2011-04 Article REM application/pdf en http://irep.iium.edu.my/15478/1/antihypertensive_paper.pdf Md. Jaffri, Juliana and Mohamed, Suhaila and Rohimi, Nordanial and Ahmad, Intan Natasya and Mohamed Mustapha, Noordin and Manap, Mohd Yazid (2011) Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats. Journal of Medicinal Food, 14 (7/8). pp. 775-783. ISSN 1096-620X http://online.liebertpub.com/doi/abs/10.1089/jmf.2010.1170 10.1089/jmf.2010.1170 |
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RM695 Physical medicine. Physical therapy Md. Jaffri, Juliana Mohamed, Suhaila Rohimi, Nordanial Ahmad, Intan Natasya Mohamed Mustapha, Noordin Manap, Mohd Yazid Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats |
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Oil palm (Elaeis guineensis) leaf extract (OPLE) possesses good ex vivo vasodilation and antioxidant properties.
This study evaluated the catechin-rich OPLE antioxidant, antihypertensive, and cardiovascular effects in normal and
nitric oxide (NO)–deficient hypertensive rats. OPLE was administered orally (500 mg=kg of body weight=day) to normotensive Wistar rats and Nx-nitro-l-arginine methyl ester (l-NAME)-induced NO-deficient hypertensive rats. OPLE significantly (P < .05) attenuated blood pressure increases, increased serum NO, reduced lipid peroxidation, and showed antioxidant effects in NO-deficient hypertensive rats. OPLE decreased the coronary arteriole wall-to-lumen ratio to near normal values under NO deficiency. Although OPLE showed good antihypertensive and antioxidant effects under NO deficiency, it was not hypotensive to normal rats and produced no chronic cardiovascular toxicity in any of the rats throughout the 12-week study. This is the first report on the in vivo antihypertensive properties of green tea catechins extracted from an alternative source,
namely, oil palm leaf, for use as a medicinal food for hypertension and cardiovascular ailments. |
format |
Article |
author |
Md. Jaffri, Juliana Mohamed, Suhaila Rohimi, Nordanial Ahmad, Intan Natasya Mohamed Mustapha, Noordin Manap, Mohd Yazid |
author_facet |
Md. Jaffri, Juliana Mohamed, Suhaila Rohimi, Nordanial Ahmad, Intan Natasya Mohamed Mustapha, Noordin Manap, Mohd Yazid |
author_sort |
Md. Jaffri, Juliana |
title |
Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats |
title_short |
Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats |
title_full |
Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats |
title_fullStr |
Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats |
title_full_unstemmed |
Antihypertensive and cardiovascular effects of catechin-rich oil palm (Elaeis guineensis) leaf extract in nitric oxide–deficient rats |
title_sort |
antihypertensive and cardiovascular effects of catechin-rich oil palm (elaeis guineensis) leaf extract in nitric oxide–deficient rats |
publisher |
Mary Ann Liebert Inc. |
publishDate |
2011 |
url |
http://irep.iium.edu.my/15478/1/antihypertensive_paper.pdf http://irep.iium.edu.my/15478/ http://online.liebertpub.com/doi/abs/10.1089/jmf.2010.1170 |
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1643607020067094528 |
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13.160551 |