Cooperation between ARID3A and p53 in the transcriptional activation of p21WAF1 in response to DNA damage

• Main Authors: Lestari, Widya, Arief Ichwan, Solachuddin Jauhari, Otsu, Megumi, Yamada, Shunpei, Shimizu, Shihoko, Ikeda , Masa Aki
• Format: Article
• Language: English
• Published: ELSEVIER 2012
• Subjects: RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/13887/1/Cooperation_between_ARID3A_and_p53_in_the_transcriptional_activation.pdf; http://irep.iium.edu.my/13887/; http://www.sciencedirect.com/science/article/pii/S0006291X11022054; http://dx.doi.org/10.1016/j.bbrc.2011.12.003

ARID3A/DRIL1/Bright is a family member of the AT rich interaction domain (ARID) DNA-binding proteins that are involved in diverse biological processes. We have reported that p53 activates ARID3A transcription, and ARID3A overexpression induces G1 arrest. However, the role of ARID3A in the p53 pathwa...