LL5 directs the translocation of Filamin A and SHIP2 to sites of phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulation, and PtdIns(3,4,5)P3 localization is mutually modified by co-recruited SHIP2

• Main Authors: Takabayashi, Tetsuji, Xie, Min-Jue, Takeuchi, Seiji, Kawasaki, Motomi, Yagi, Hideshi, Okamoto, Masayuki, Rahman, Mohammad Tariqur, Malik, Fawzia, Kuroda, Kazuki, Kubota, Chikara, Fujieda, Shigeharu, Nagano, Takashi, Sato, Makoto
• Format: Article
• Language: English
• Published: American Society for Biochemistry and Molecular Biology Inc. 2010
• Subjects: RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry
• Online Access: http://irep.iium.edu.my/12444/1/LL5B_Direct_the_translocation_of_filamin_A_sites.pdf; http://irep.iium.edu.my/12444/; http://dx.doi.org/10.1074/jbc.M109.081901

Phosphatidylinositol 3,4,5-triphosphate (PtdIns(3,4,5)P3) accumulates at the leading edge of migrating cells and works, at least partially, as both a compass to indicate directionality and a hub for subsequent intracellular events. However, how PtdIns(3,4,5)P3 regulates the migratory machinery has n...