New α-glucosidase inhibitors and antioxidants in optimized Psychotria malayana Jack leaves extract identified by gC-MS-based metabolomics and in silico molecular docking

• Main Authors: Syed Mohamad, Sharifah Nurul Akilah, Khatib, Alfi, Mat So'ad, Siti Zaiton, Ahmed, Qamar Uddin, Ibrahim, Zalikha, Saiman, Mohd Zuwairi, Hariyadi, Dewi Melani, Susilo, Agus, Samdani, Mohammad Shahzad, Abbas, Syed Atif, Kanakal, Mahibub Mahamadsa, Khan, Abdullah, Kashif, Mohammad
• Format: Article
• Language: English; English
• Published: Taylor & Francis Group 2024
• Subjects: RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/116934/1/116934_New%20%CE%B1-glucosidase%20inhibitors%20and%20antioxidants%20in%20optimized%20Psychotria%20malayana%20Jack%20leaves.pdf; http://irep.iium.edu.my/116934/7/116934_New%20%CE%B1-glucosidase%20inhibitors%20and%20antioxidants%20in%20optimized%20Psychotria%20malayana%20Jack%20leaves_Scopus.pdf; http://irep.iium.edu.my/116934/; https://www.tandfonline.com/doi/full/10.1080/14786419.2024.2440789; https://doi.org/10.1080/14786419.2024.2440789

Our earlier research demonstrated α-glucosidase inhibitory (AGI) and antioxidant activities of the optimised extract of Psychotria malayana leaves. It was reported having numerous compounds, although it was unclear which compounds exhibit the bioactivities as well as their binding interaction to the...