Proliv Essence-3 (PE3): a nutricosmetic botanical blend as a dietary beverage for skin wellness and general health

• Main Authors: Zakaria, Nor Hafizah, Abdul Majid, Fadzilah Adibah, Awang, Anis Fadhlina Izyani, Abdul Hamid, Siti Noorwanie, Anuar, Mohd Nur Nasyriq, Tengku Aziz, Tengku Nurfarhana
• Format: Article
• Language: English
• Published: Maximum Academic Press 2024
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/112102/2/112102_Proliv%20Essence-3%20%28PE3%29.pdf; http://irep.iium.edu.my/112102/; https://www.maxapress.com/data/article/bpr/preview/pdf/bpr-0024-0008.pdf; https://doi.org/10.48130/bpr-0024-0008

A natural product-based dietary approach could offer a safe and effective method for slowing down or preventing age-related deterioration in skin appearance and function, including issues like hyperpigmentation, dryness and wrinkles. Proliv Essence-3 (PE3) is a botanical beverage, meant for oral consumption with a unique formulation of three selected fruit extracts, Momordica charantia, Malus domestica, and Psidium guajava. Its purpose is to enhance both skin health and overall well-being from within. Proximate composition, presence of gallic acid and antioxidant activity of PE3 extract were determined. Elastase and tyrosinase inhibition assays were employed to investigate the anti-aging and whitening effects, respectively. The in vitro scratch assay and epidermal growth factor (EGF) assay were carried out to evaluate skin cell growth promotion and rejuvenation. The cytotoxicity analysis was carried out via neutral red uptake. The proximate analysis revealed that the product had a high moisture content and low amounts of calories. High-performance liquid chromatography (HPLC) analysis estimated 11.22 mg of gallic acid in 1 g of PE3 extract. PE3 exhibited a DPPH-IC50 value of 148.60 ± 1.52 μg/mL and an ABTS-IC50 value of 91.18 ± 1.15 μg/mL. The IC50 values for tyrosinase and elastase inhibition assays were 160.20 ± 1.81 μg/mL and 65.49 ± 0.38 μg/mL, respectively. PE3 was also discovered to be non-cytotoxic, and it enhanced the migration and proliferation of HSF1184 cells. EGF secretion was detected in PE3-treated HSF1184. This study provided preliminary evidence supporting the potential of PE3 as a nutricosmetical botanical beverage for promoting skin beautification and general health.