Unlocking the potential of chitosan-based polymeric nanoparticles for the treatment of neurological disorders
Neurological disorders are the diseases associated with the central and peripheral nervous system. They are among the most serious and prevalent diseases nowadays. However, most of the pharmacological agents used to treat neurological disorders demonstrate severe toxicities and side effects, along...
Saved in:
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English English |
Published: |
Mashhad University of Medical Sciences
2024
|
Subjects: | |
Online Access: | http://irep.iium.edu.my/111808/2/111808_Unlocking%20the%20potential%20of%20chitosan-based%20polymeric_SCOPUS.pdf http://irep.iium.edu.my/111808/3/111808_Unlocking%20the%20potential%20of%20chitosan-based%20polymeric.pdf http://irep.iium.edu.my/111808/ https://nmj.mums.ac.ir/article_23731_b81f0abec27f03bdb5de774fd311cab7.pdf |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my.iium.irep.111808 |
---|---|
record_format |
dspace |
spelling |
my.iium.irep.1118082024-04-19T07:13:27Z http://irep.iium.edu.my/111808/ Unlocking the potential of chitosan-based polymeric nanoparticles for the treatment of neurological disorders Eissa, Manar Hashim, Yumi Zuhanis Has-Yun Badawi, Noha Q Science (General) Neurological disorders are the diseases associated with the central and peripheral nervous system. They are among the most serious and prevalent diseases nowadays. However, most of the pharmacological agents used to treat neurological disorders demonstrate severe toxicities and side effects, along with failure to achieve the desired outcomes due to their inability to cross the blood-brain barrier (BBB). Therefore, efforts have been made to develop potential drug carriers that can enhance the penetration of various therapeutic agents across the BBB. Due to the remarkable selectivity of nanoparticles and their ability to penetrate the BBB, they have attracted enormous interest as a viable solution to overcome these challenges. Polymeric nanoparticles used as drug delivery systems, in particular, demonstrated multiple advantages over traditional drug delivery systems in the treatment of neurological and psychological disorders due to several beneficial properties. This minireview article discusses the current literature on the use of chitosan nanoparticles in particular as promising carriers for delivering therapeutic agents to the brain for the treatment of different neurological diseases. The article emphasizes the advantages of using chitosan over other natural and synthetic polymers, and illustrates the methods of preparation of chitosan nanoparticles, in addition to the characterization of chitosan-based nanoparticles. The article also discusses the specific application of chitosan-based nanoparticles for brain targeting with the aim of the treatment of neurological disorders. Furthermore, challenges and future prospects were also discussed Mashhad University of Medical Sciences 2024-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/111808/2/111808_Unlocking%20the%20potential%20of%20chitosan-based%20polymeric_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/111808/3/111808_Unlocking%20the%20potential%20of%20chitosan-based%20polymeric.pdf Eissa, Manar and Hashim, Yumi Zuhanis Has-Yun and Badawi, Noha (2024) Unlocking the potential of chitosan-based polymeric nanoparticles for the treatment of neurological disorders. Nanomedicine Journal, 10 (2). pp. 107-118. ISSN 2322-3049 E-ISSN 2322-5904 https://nmj.mums.ac.ir/article_23731_b81f0abec27f03bdb5de774fd311cab7.pdf 10.22038/NMJ.2024.74564.1812 |
institution |
Universiti Islam Antarabangsa Malaysia |
building |
IIUM Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
International Islamic University Malaysia |
content_source |
IIUM Repository (IREP) |
url_provider |
http://irep.iium.edu.my/ |
language |
English English |
topic |
Q Science (General) |
spellingShingle |
Q Science (General) Eissa, Manar Hashim, Yumi Zuhanis Has-Yun Badawi, Noha Unlocking the potential of chitosan-based polymeric nanoparticles for the treatment of neurological disorders |
description |
Neurological disorders are the diseases associated with the central and peripheral nervous system. They are
among the most serious and prevalent diseases nowadays. However, most of the pharmacological agents
used to treat neurological disorders demonstrate severe toxicities and side effects, along with failure to
achieve the desired outcomes due to their inability to cross the blood-brain barrier (BBB). Therefore, efforts
have been made to develop potential drug carriers that can enhance the penetration of various therapeutic
agents across the BBB. Due to the remarkable selectivity of nanoparticles and their ability to penetrate the
BBB, they have attracted enormous interest as a viable solution to overcome these challenges. Polymeric
nanoparticles used as drug delivery systems, in particular, demonstrated multiple advantages over traditional
drug delivery systems in the treatment of neurological and psychological disorders due to several beneficial
properties. This minireview article discusses the current literature on the use of chitosan nanoparticles in
particular as promising carriers for delivering therapeutic agents to the brain for the treatment of different
neurological diseases. The article emphasizes the advantages of using chitosan over other natural and
synthetic polymers, and illustrates the methods of preparation of chitosan nanoparticles, in addition to
the characterization of chitosan-based nanoparticles. The article also discusses the specific application of
chitosan-based nanoparticles for brain targeting with the aim of the treatment of neurological disorders.
Furthermore, challenges and future prospects were also discussed |
format |
Article |
author |
Eissa, Manar Hashim, Yumi Zuhanis Has-Yun Badawi, Noha |
author_facet |
Eissa, Manar Hashim, Yumi Zuhanis Has-Yun Badawi, Noha |
author_sort |
Eissa, Manar |
title |
Unlocking the potential of chitosan-based polymeric nanoparticles for the treatment of neurological disorders |
title_short |
Unlocking the potential of chitosan-based polymeric nanoparticles for the treatment of neurological disorders |
title_full |
Unlocking the potential of chitosan-based polymeric nanoparticles for the treatment of neurological disorders |
title_fullStr |
Unlocking the potential of chitosan-based polymeric nanoparticles for the treatment of neurological disorders |
title_full_unstemmed |
Unlocking the potential of chitosan-based polymeric nanoparticles for the treatment of neurological disorders |
title_sort |
unlocking the potential of chitosan-based polymeric nanoparticles for the treatment of neurological disorders |
publisher |
Mashhad University of Medical Sciences |
publishDate |
2024 |
url |
http://irep.iium.edu.my/111808/2/111808_Unlocking%20the%20potential%20of%20chitosan-based%20polymeric_SCOPUS.pdf http://irep.iium.edu.my/111808/3/111808_Unlocking%20the%20potential%20of%20chitosan-based%20polymeric.pdf http://irep.iium.edu.my/111808/ https://nmj.mums.ac.ir/article_23731_b81f0abec27f03bdb5de774fd311cab7.pdf |
_version_ |
1797904625774362624 |
score |
13.18916 |