Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger

Biotransformation is acknowledged as one of the green chemistry methods to synthesis various analogues for further valorization of natural product compounds chemistry and bioactivities. It has huge advantage over chemical synthesis due to its cost-efficiency and higher selectivity. In this work, a x...

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Main Authors: Aminudin, Nurul Iman, Abdul Aziz, Ahmad Amzar, Zainal Abidin, Zaima Azira, Darnis, Deny Susanti, Bakhtiar, M. Taher
Format: Article
Language:English
English
Published: Taylor & Francis 2024
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Online Access:http://irep.iium.edu.my/111797/2/111797_Enantioselective%20dihydroxylation%20of%20xanthorrhizol%20from%20Curcuma%20xanthorrhiza.pdf
http://irep.iium.edu.my/111797/14/111797_Enantioselective%20dihydroxylation%20of%20xanthorrhizol%20from%20Curcuma%20xanthorrhiza_Scopus.pdf
http://irep.iium.edu.my/111797/
https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2161543
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spelling my.iium.irep.1117972024-08-02T00:49:05Z http://irep.iium.edu.my/111797/ Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger Aminudin, Nurul Iman Abdul Aziz, Ahmad Amzar Zainal Abidin, Zaima Azira Darnis, Deny Susanti Bakhtiar, M. Taher QD Chemistry Biotransformation is acknowledged as one of the green chemistry methods to synthesis various analogues for further valorization of natural product compounds chemistry and bioactivities. It has huge advantage over chemical synthesis due to its cost-efficiency and higher selectivity. In this work, a xanthorrhizol derivatives, namely (7R,10S)-10,11-dihydro-10,11-dihydroxyxanthorrhizol was produced in 60% yield from the biotransformation process utilizing A. niger. The structure of the compound was established by extensive spectroscopic methods and comparison with literature data. This biotransformation successfully afforded enantioselective dihydroxylation reaction via green chemistry route. This is the first report on both biotransformation of xanthorrhizol and utilization of A. niger as its biocatalyst. Taylor & Francis 2024-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/111797/2/111797_Enantioselective%20dihydroxylation%20of%20xanthorrhizol%20from%20Curcuma%20xanthorrhiza.pdf application/pdf en http://irep.iium.edu.my/111797/14/111797_Enantioselective%20dihydroxylation%20of%20xanthorrhizol%20from%20Curcuma%20xanthorrhiza_Scopus.pdf Aminudin, Nurul Iman and Abdul Aziz, Ahmad Amzar and Zainal Abidin, Zaima Azira and Darnis, Deny Susanti and Bakhtiar, M. Taher (2024) Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger. Natural Product Research, 38 (9). pp. 1583-1590. ISSN 1478-6419 E-ISSN 1478-6427 https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2161543 10.1080/14786419.2022.2161543
institution Universiti Islam Antarabangsa Malaysia
building IIUM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider International Islamic University Malaysia
content_source IIUM Repository (IREP)
url_provider http://irep.iium.edu.my/
language English
English
topic QD Chemistry
spellingShingle QD Chemistry
Aminudin, Nurul Iman
Abdul Aziz, Ahmad Amzar
Zainal Abidin, Zaima Azira
Darnis, Deny Susanti
Bakhtiar, M. Taher
Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger
description Biotransformation is acknowledged as one of the green chemistry methods to synthesis various analogues for further valorization of natural product compounds chemistry and bioactivities. It has huge advantage over chemical synthesis due to its cost-efficiency and higher selectivity. In this work, a xanthorrhizol derivatives, namely (7R,10S)-10,11-dihydro-10,11-dihydroxyxanthorrhizol was produced in 60% yield from the biotransformation process utilizing A. niger. The structure of the compound was established by extensive spectroscopic methods and comparison with literature data. This biotransformation successfully afforded enantioselective dihydroxylation reaction via green chemistry route. This is the first report on both biotransformation of xanthorrhizol and utilization of A. niger as its biocatalyst.
format Article
author Aminudin, Nurul Iman
Abdul Aziz, Ahmad Amzar
Zainal Abidin, Zaima Azira
Darnis, Deny Susanti
Bakhtiar, M. Taher
author_facet Aminudin, Nurul Iman
Abdul Aziz, Ahmad Amzar
Zainal Abidin, Zaima Azira
Darnis, Deny Susanti
Bakhtiar, M. Taher
author_sort Aminudin, Nurul Iman
title Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger
title_short Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger
title_full Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger
title_fullStr Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger
title_full_unstemmed Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger
title_sort enantioselective dihydroxylation of xanthorrhizol from curcuma xanthorrhiza via biotransformation using aspergillus niger
publisher Taylor & Francis
publishDate 2024
url http://irep.iium.edu.my/111797/2/111797_Enantioselective%20dihydroxylation%20of%20xanthorrhizol%20from%20Curcuma%20xanthorrhiza.pdf
http://irep.iium.edu.my/111797/14/111797_Enantioselective%20dihydroxylation%20of%20xanthorrhizol%20from%20Curcuma%20xanthorrhiza_Scopus.pdf
http://irep.iium.edu.my/111797/
https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2161543
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score 13.18916