Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger
Biotransformation is acknowledged as one of the green chemistry methods to synthesis various analogues for further valorization of natural product compounds chemistry and bioactivities. It has huge advantage over chemical synthesis due to its cost-efficiency and higher selectivity. In this work, a x...
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my.iium.irep.1117972024-08-02T00:49:05Z http://irep.iium.edu.my/111797/ Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger Aminudin, Nurul Iman Abdul Aziz, Ahmad Amzar Zainal Abidin, Zaima Azira Darnis, Deny Susanti Bakhtiar, M. Taher QD Chemistry Biotransformation is acknowledged as one of the green chemistry methods to synthesis various analogues for further valorization of natural product compounds chemistry and bioactivities. It has huge advantage over chemical synthesis due to its cost-efficiency and higher selectivity. In this work, a xanthorrhizol derivatives, namely (7R,10S)-10,11-dihydro-10,11-dihydroxyxanthorrhizol was produced in 60% yield from the biotransformation process utilizing A. niger. The structure of the compound was established by extensive spectroscopic methods and comparison with literature data. This biotransformation successfully afforded enantioselective dihydroxylation reaction via green chemistry route. This is the first report on both biotransformation of xanthorrhizol and utilization of A. niger as its biocatalyst. Taylor & Francis 2024-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/111797/2/111797_Enantioselective%20dihydroxylation%20of%20xanthorrhizol%20from%20Curcuma%20xanthorrhiza.pdf application/pdf en http://irep.iium.edu.my/111797/14/111797_Enantioselective%20dihydroxylation%20of%20xanthorrhizol%20from%20Curcuma%20xanthorrhiza_Scopus.pdf Aminudin, Nurul Iman and Abdul Aziz, Ahmad Amzar and Zainal Abidin, Zaima Azira and Darnis, Deny Susanti and Bakhtiar, M. Taher (2024) Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger. Natural Product Research, 38 (9). pp. 1583-1590. ISSN 1478-6419 E-ISSN 1478-6427 https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2161543 10.1080/14786419.2022.2161543 |
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QD Chemistry Aminudin, Nurul Iman Abdul Aziz, Ahmad Amzar Zainal Abidin, Zaima Azira Darnis, Deny Susanti Bakhtiar, M. Taher Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger |
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Biotransformation is acknowledged as one of the green chemistry methods to synthesis various analogues for further valorization of natural product compounds chemistry and bioactivities. It has huge advantage over chemical synthesis due to its cost-efficiency and higher selectivity. In this work, a xanthorrhizol derivatives, namely (7R,10S)-10,11-dihydro-10,11-dihydroxyxanthorrhizol was produced in 60% yield from the biotransformation process utilizing A. niger. The structure of the compound was established by extensive spectroscopic methods and comparison with literature data. This biotransformation successfully afforded enantioselective dihydroxylation reaction via green chemistry route. This is the first report on both biotransformation of xanthorrhizol and utilization of A. niger as its biocatalyst. |
format |
Article |
author |
Aminudin, Nurul Iman Abdul Aziz, Ahmad Amzar Zainal Abidin, Zaima Azira Darnis, Deny Susanti Bakhtiar, M. Taher |
author_facet |
Aminudin, Nurul Iman Abdul Aziz, Ahmad Amzar Zainal Abidin, Zaima Azira Darnis, Deny Susanti Bakhtiar, M. Taher |
author_sort |
Aminudin, Nurul Iman |
title |
Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger |
title_short |
Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger |
title_full |
Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger |
title_fullStr |
Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger |
title_full_unstemmed |
Enantioselective dihydroxylation of xanthorrhizol from Curcuma xanthorrhiza via biotransformation using Aspergillus Niger |
title_sort |
enantioselective dihydroxylation of xanthorrhizol from curcuma xanthorrhiza via biotransformation using aspergillus niger |
publisher |
Taylor & Francis |
publishDate |
2024 |
url |
http://irep.iium.edu.my/111797/2/111797_Enantioselective%20dihydroxylation%20of%20xanthorrhizol%20from%20Curcuma%20xanthorrhiza.pdf http://irep.iium.edu.my/111797/14/111797_Enantioselective%20dihydroxylation%20of%20xanthorrhizol%20from%20Curcuma%20xanthorrhiza_Scopus.pdf http://irep.iium.edu.my/111797/ https://www.tandfonline.com/doi/full/10.1080/14786419.2022.2161543 |
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1806442135309778944 |
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13.18916 |