GBA1 rs3115534 is associated with REM sleep behavior disorder in Parkinson’s disease in Nigerians

• Main Authors: Ojo, Oluwadamilola Omolara, Bandres-Ciga, Sara, Makarious, Mary B., Crea, Peter Wild, Hernandez, Dena G., Houlden, Henry, Rizig, Mie, Singleton, Andrew B., Noyce, Alastair J., Nalls, Mike A., Blauwendraat, Cornelis, Okubadejo, Njideka Ulunma, Mohamed, Wael Mohamed Yousef
• Format: Article
• Language: English; English
• Published: Wiley-Blackwell 2024
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/111342/7/111342_GBA1%20rs3115534%20Is%20associated%20with%20REM%20sleep.pdf; http://irep.iium.edu.my/111342/13/111342_GBA1%20rs3115534%20Is%20Associated%20with%20REM%20Sleep%20Behavior%20Disorder%20in%20Parkinson%27s%20Disease%20in%20Nigerians_SCOPUS.pdf; http://irep.iium.edu.my/111342/; https://movementdisorders.onlinelibrary.wiley.com/doi/pdfdirect/10.1002/mds.29753?download=true; https://doi.org/10.1002/mds.29753

Background:Rapid eye movement(REM) sleep behavior disorder (RBD) is an early fea-ture of Parkinson’s disease (PD) and dementia withLewy bodies (DLB). Damaging coding variants inGlucocerebrosidase (GBA1) are a genetic risk factorfor RBD. Recently, a population-specific non-codingrisk variant (rs31155...