High performance liquid chromatographic method optimized by Box-Behnken design model to determine caffeine in pharmaceutical preparations and urine samples

• Main Authors: Azmi, Syed Najmul Hejaz, Nasir Al Rawahi, Wafa Aqib, Ibrahim Al Yahyai, Arwa, Ali Al Qasimi, Asma, Saif Al Fuliti, Kothar, Said Al Qalhati, Omayma, Rahman, Nafisur, Ahmed, Qamar Uddin
• Format: Article
• Language: English; English
• Published: Elsevier 2024
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/110717/1/110717_High%20performance%20liquid%20chromatographic%20method%20optimized%20by%20Box-Behnken%20design%20model.pdf; http://irep.iium.edu.my/110717/7/110717_High%20performance%20liquid%20chromatographic%20method%20optimized%20by%20Box-Behnken%20design%20model_SCOPUS.pdf; http://irep.iium.edu.my/110717/; https://www.sciencedirect.com/science/article/abs/pii/S1570023224000436

A UV-HPLC method optimized by Box-Behnken design model was developed to determine caffeine in pharmaceutical preparations and urine samples. The chromatographic conditions followed were mobile phase: methanol/water/ citrate buffer (pH 4.6) (40:25:35, v/v/v), AcclaimTM Dionex C18 column (ODS 100A˚, 5...