Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults with nonhypoxic ischaemic acute brain injuries and conditions in the intensive care unit (Mega-ROX Brains)

• Main Authors: Young, Paul J., Al-Fares, Abdulrahman, Aryal, Diptesh, Arabi, Yaseen M, Ashraf, Muhammad Sheharyar, Bagshaw, Sean M., Mat Nor, Mohd Basri, Beane, Abigail, Borghi, Giovanni, de Oliveira Manoel, Airton L., Dullawe, Layoni, Fazla, Fathima, Fuji, Tomoko, Haniffa, Rashan, Hodgson, Carol, Hunt, Anna, Lawrence, Cassie, Mackle, Diane, Mangal, Krishore, Nichol, Alistair, Olatunji, Shaanti, Rashan, Aasiyah, Rashan, Sumayyah, Tomazini, Bruno, Kasza, Jessica
• Format: Article
• Language: English; English
• Published: Elsevier 2023
• Subjects: RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
• Online Access: http://irep.iium.edu.my/110192/7/110192_Protocol%20and%20statistical%20analysis%20plan_SCOPUS.pdf; http://irep.iium.edu.my/110192/8/110192_Protocol%20and%20statistical%20analysis%20plan.pdf; http://irep.iium.edu.my/110192/; https://www.sciencedirect.com/science/article/pii/S1441277223000133/pdfft?md5=c24679375b7be82537db0cf01d3be68a&pid=1-s2.0-S1441277223000133-main.pdf

Background: The effect of conservative vs. liberal oxygen therapy on 90-day in-hospital mortality in adults who have nonhypoxic ischaemic encephalopathy acute brain injuries and conditions and are receiving invasive mechanical ventilation in the intensive care unit (ICU) is uncertain. Objective:...