A protocol for an international, multicentre pharmacokinetic study for screening Antifungal exposure in intensive care units: the SAFE-ICU study

• Main Authors: Roberts, Jason A., Sime, Fekade, Lipman, Jeffrey, Hernandez-Mitre, Maria Patricia, Baptista, João P, Brüggemann, Roger J., Darvall, Jai, Waele, Jan J. De, Dimopoulos, George, Lefrant, Jean-Yves, Mat Nor, Mohd Basri, Rello, Jordi, Seoane, Leonardo, Slavin, Monica A., Valkonen, Miia Maaria, Venditti, Mario, Wong, Wai Tat, Zeitlinger, Markus, Roger, Claire
• Format: Article
• Language: English; English
• Published: Elsevier 2023
• Subjects: RC82 Medical Emergencies, Critical Care, Intensive Care, First Aid
• Online Access: http://irep.iium.edu.my/110190/7/110190_A%20protocol%20for%20an%20international%2C%20multicentre%20pharmacokinetic_SCOPUS.pdf; http://irep.iium.edu.my/110190/8/110190_A%20protocol%20for%20an%20international%2C%20multicentre%20pharmacokinetic.pdf; http://irep.iium.edu.my/110190/; https://www.sciencedirect.com/science/article/pii/S1441277223000029/pdfft?md5=0a3d428ce8b7b60a0f17423e2ea0b1ec&pid=1-s2.0-S1441277223000029-main.pdf; https://doi.org/10.1016/j.ccrj.2023.04.002

Objective: To describe whether contemporary dosing of antifungal drugs achieves therapeutic exposures in critically ill patients that are associated with optimal outcomes. Adequate antifungal therapy is a key determinant of survival of critically ill patients with fungal infections. Critical illne...