Retinoic acid targeting DGAT2 in non-alcoholic fatty liver disease model

• Main Authors: Ahmed Mohamed Ben-Amer, Nawal, Buyong, Zunariah, Abdullah, Nor Zamzila, Hamdan, Asmah Hanim, Ab Rahman, Jamalludin, Kuttulebbai Naina Mohamed Salam, Sirajudeen
• Format: Article
• Language: English
• Published: Universiti Kebangsaan Malaysia 2023
• Subjects: R Medicine (General)
• Online Access: http://irep.iium.edu.my/109211/7/109211_Retinoic%20Acid%20targeting%20DGAT2%20in%20non-alcoholic.pdf; http://irep.iium.edu.my/109211/

Introduction: Nonalcoholic fatty liver disease (NAFLD) is caused by triglyceride (TG) accumulation in the hepatocyte. The initial reversible stage is steatosis, and if left untreated may progress to steatohepatitis, marked by necrosis and inflammation, eventually leading to cirrhosis. Currently,...