Chemical composition of essential oil from lindera subumbelliflora kosterm and its effect on the susceptibility and biofilm activities of candida albicans and streptococcus mutans

• Main Authors: Mohd Zain, Nur Nabilah, Wan salleh, Wan Mohd Nuzul hakimi, Arzmi, Mohd Hafiz, Salihua, Abubakar Siddiq, Ab Ghani, Nurunajah
• Format: Article
• Language: English; English
• Published: Taylor & Francis 2023
• Subjects: QR Microbiology
• Online Access: http://irep.iium.edu.my/108241/7/108241_Chemical%20composition%20of%20essential%20oil%20from%20lindera%20subumbelliflora%20kosterm.pdf; http://irep.iium.edu.my/108241/8/108241_Chemical%20composition%20of%20essential%20oil%20from%20lindera%20subumbelliflora%20kosterm_Scopus.pdf; http://irep.iium.edu.my/108241/; https://www.tandfonline.com/doi/abs/10.1080/14786419.2023.2278164; https://doi.org/10.1080/14786419.2023.2278164

the chemical composition of the essential oil of Lindera subumbel- liflora (Lauraceae) was investigated for the first time. the essential oil was obtained by hydrodistillation and fully characterised by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-mS). the antifungal activity of L. subumbelliflora essential oil was tested against Candida albicans and Streptococcus mutans using the broth microdilution assay, whereas the microbial biofilms were determined using a semi-quantitative static biofilm. a total of 28 components (99.6%) were successfully identified, which were characterised by β-eudesmol (14.6%), cis-α-bergamotene (11.0%), α-copaene (8.5%), dodecen-1-ol (8.5%), and (E)-nerolidol (8.3%). the essential oil exhibited activity against Candida albicans and Streptococcus mutans with miC values of 250 and 500 μg/mL, respectively. the essential oil increased the biofilm of Candida albi- cans by 38.25%, however, decreased the biofilm of Streptococcus mutans by 47.89% when treated with 500μg/mL. thus, the essen- tial oil has a promising application in dentistry via inhibition of the growth of Candida albicans and Streptococcus mutans. However, the antibiofilm activity of the essential oil is only applicable for cario- genic Streptococcus mutans.