Revisiting genetics of cleft lip with or without cleft palate and cleft palate only: a narrative review
Cleft lip with or without cleft palate (CLP) and cleft palate only (CP) are the most common orofacial deformities observed in humans where almost 1 in 700 to 1 in 2000 babies born each year are affected worldwide. This condition occurs when the specific and independently derived facial primordia...
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Penerbit Universiti Sains Malaysia
2023
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Online Access: | http://irep.iium.edu.my/107536/14/107536_Revisiting%20genetics%20of%20cleft%20lip%20with%20or%20without%20cleft%20palate.pdf http://irep.iium.edu.my/107536/ https://aos.usm.my/docs/Vol_18/aos-2023-0018.pdf https://doi.org/10.21315/aos2023.1802.RV01 |
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my.iium.irep.1075362024-01-24T07:38:39Z http://irep.iium.edu.my/107536/ Revisiting genetics of cleft lip with or without cleft palate and cleft palate only: a narrative review Saiful Zaabaa, Mohamad Irsyad Mokhtar@Makhtar, Khairani Idah Rajion, Zainul Ahmad RK Dentistry Cleft lip with or without cleft palate (CLP) and cleft palate only (CP) are the most common orofacial deformities observed in humans where almost 1 in 700 to 1 in 2000 babies born each year are affected worldwide. This condition occurs when the specific and independently derived facial primordial fails to fuse together, hence forming the cleft of the lip and palate or the palate alone. These orofacial abnormalities can be divided into syndromic and non-syndromic where the deformities are either associated with other disorders or present on their own, respectively. It is important to understand every step in the lip and palate development during embryonic stage to pinpoint the exact problem affecting the normal development of the human face. With current technologies, more genes are identified to be associated and caused CLP and CP in humans. Therefore, this review aimed to elaborate the latest updates on the genetics of CLP and CP. Polymorphism in some of the genes has been associated with the incidence of these anomalies. Identification of these genes provides new knowledge on how these craniofacial abnormalities occur and hopefully will enable earlier treatment of these deformities to be implemented. Penerbit Universiti Sains Malaysia 2023-12-20 Article PeerReviewed application/pdf en http://irep.iium.edu.my/107536/14/107536_Revisiting%20genetics%20of%20cleft%20lip%20with%20or%20without%20cleft%20palate.pdf Saiful Zaabaa, Mohamad Irsyad and Mokhtar@Makhtar, Khairani Idah and Rajion, Zainul Ahmad (2023) Revisiting genetics of cleft lip with or without cleft palate and cleft palate only: a narrative review. Archives of Orofacial Sciences, 18 (2). pp. 73-88. ISSN 1823-8602 E-ISSN 2231-7163 https://aos.usm.my/docs/Vol_18/aos-2023-0018.pdf https://doi.org/10.21315/aos2023.1802.RV01 |
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RK Dentistry Saiful Zaabaa, Mohamad Irsyad Mokhtar@Makhtar, Khairani Idah Rajion, Zainul Ahmad Revisiting genetics of cleft lip with or without cleft palate and cleft palate only: a narrative review |
description |
Cleft lip with or without cleft palate (CLP) and cleft palate only (CP) are the most common orofacial
deformities observed in humans where almost 1 in 700 to 1 in 2000 babies born each year are affected
worldwide. This condition occurs when the specific and independently derived facial primordial fails to
fuse together, hence forming the cleft of the lip and palate or the palate alone. These orofacial
abnormalities can be divided into syndromic and non-syndromic where the deformities are either
associated with other disorders or present on their own, respectively. It is important to understand every
step in the lip and palate development during embryonic stage to pinpoint the exact problem affecting the
normal development of the human face. With current technologies, more genes are identified to be
associated and caused CLP and CP in humans. Therefore, this review aimed to elaborate the latest
updates on the genetics of CLP and CP. Polymorphism in some of the genes has been associated with the
incidence of these anomalies. Identification of these genes provides new knowledge on how these
craniofacial abnormalities occur and hopefully will enable earlier treatment of these deformities to be
implemented. |
format |
Article |
author |
Saiful Zaabaa, Mohamad Irsyad Mokhtar@Makhtar, Khairani Idah Rajion, Zainul Ahmad |
author_facet |
Saiful Zaabaa, Mohamad Irsyad Mokhtar@Makhtar, Khairani Idah Rajion, Zainul Ahmad |
author_sort |
Saiful Zaabaa, Mohamad Irsyad |
title |
Revisiting genetics of cleft lip with or without cleft palate
and cleft palate only: a narrative review |
title_short |
Revisiting genetics of cleft lip with or without cleft palate
and cleft palate only: a narrative review |
title_full |
Revisiting genetics of cleft lip with or without cleft palate
and cleft palate only: a narrative review |
title_fullStr |
Revisiting genetics of cleft lip with or without cleft palate
and cleft palate only: a narrative review |
title_full_unstemmed |
Revisiting genetics of cleft lip with or without cleft palate
and cleft palate only: a narrative review |
title_sort |
revisiting genetics of cleft lip with or without cleft palate
and cleft palate only: a narrative review |
publisher |
Penerbit Universiti Sains Malaysia |
publishDate |
2023 |
url |
http://irep.iium.edu.my/107536/14/107536_Revisiting%20genetics%20of%20cleft%20lip%20with%20or%20without%20cleft%20palate.pdf http://irep.iium.edu.my/107536/ https://aos.usm.my/docs/Vol_18/aos-2023-0018.pdf https://doi.org/10.21315/aos2023.1802.RV01 |
_version_ |
1789424021853437952 |
score |
13.18916 |