Molecular docking and ADME profiles of β-Carboline analogues as potential antibiotic agents targeting DNA gyrase

• Main Authors: Abdul Aziz, Ahmad Amzar, Aminudin, Nurul Iman, Abd Hamid, Shafida, Pungot, Noor Hidayah, Hamzah, Nurasyikin
• Format: Article
• Language: English; English
• Published: Malaysian Institute of Chemistry (Institut Kimia Malaysia) 2023
• Subjects: QD Chemistry
• Online Access: http://irep.iium.edu.my/106834/8/106834_Molecular%20docking%20and%20ADME%20profiles%20of%20%CE%B2-Carboline.pdf; http://irep.iium.edu.my/106834/7/106834_Molecular%20docking%20and%20ADME%20profiles%20of%20%CE%B2-Carboline_SCOPUS.pdf; http://irep.iium.edu.my/106834/; https://ikm.org.my/publications/malaysian-journal-of-chemistry/view-abstract.php?abs=J0044-d167501

Antibiotic resistance remains a major threat to humans worldwide, owing to the ability of bacteria and fungi to mutate over time, as well as a dramatic decline in the antibiotic pipeline. Plants are widely recognised as sources for various bioactive secondary metabolites that can be developed as a h...