Specific microRNAs among milk siblings: an epigenetics approach towards understanding the basis of milk kinship
Milk kinship is an Islamic belief described as a relationship established when infants receive breast milk from non-biological mothers. This form of kinship is said to bear a very close resemblance to blood relation whereby the recipients’ infants are regarded as milk siblings to the biological chi...
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Universiti Putra Malaysia
2023
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my.iium.irep.1063372024-06-21T02:55:31Z http://irep.iium.edu.my/106337/ Specific microRNAs among milk siblings: an epigenetics approach towards understanding the basis of milk kinship Wan Nor Ruddin, Wan Alif Afiq Ismail, Hamizah Mohd Nor, Nurul Yaqin Kaderi, Mohd Arifin Muda, Siti Mariam Daud, Normadiah Zainuddin, Norafiza QH426 Genetics Milk kinship is an Islamic belief described as a relationship established when infants receive breast milk from non-biological mothers. This form of kinship is said to bear a very close resemblance to blood relation whereby the recipients’ infants are regarded as milk siblings to the biological children of the breastfeeding mother. Any future marriage between these individuals is forbidden likewise between the recipient infant and the nursing mother herself as they are thought to have a form of consanguinity. The consanguinity formed by virtue of milk sharing might be due to the composition of human breast milk, especially milk microRNAs that are responsible for the epigenetic modulation of gene expression. miRNAs can regulate gene expression by modulating genome-wide epigenetic status of genes, and similarly-shared genes might be the basis that has led to milk kinship formation. Thus, the objective of the present study is to identify potential lactationspecific miRNAs that are similarly shared among milk siblings and their nursing mothers. The study began with molecular extraction of milk RNA from the nursing mothers and cell-free plasma RNA from all milk siblings and their nursing mothers. The RNAs extracted from both sample types were further analyzed using NanoString nCounter® miRNA Panel Analysis (NanoString Technologies, Seattle, WA) to measure the abundance of individual miRNAs biomarkers present within the samples. This study is expected to provide scientific explanation that could divulge the secrets behind milk kinship establishment with thorough presentation on the lactation-specific miRNAs shared between milk siblings. Hence, the way for future research would be paved, making the development of milk kinship identification tool possible. Universiti Putra Malaysia 2023 Article PeerReviewed application/pdf en http://irep.iium.edu.my/106337/7/106337_Specific%20microRNAs%20Among%20Milk%20Siblings%20An%20Epigenetics.pdf Wan Nor Ruddin, Wan Alif Afiq and Ismail, Hamizah and Mohd Nor, Nurul Yaqin and Kaderi, Mohd Arifin and Muda, Siti Mariam and Daud, Normadiah and Zainuddin, Norafiza (2023) Specific microRNAs among milk siblings: an epigenetics approach towards understanding the basis of milk kinship. Asia Pacific Journal of Molecular Biology & Biotechnology, 31 (2). p. 86. ISSN 0128-7451 E-ISSN 2672-7277 https://www.msmbb.my/index.php/archive-issues |
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QH426 Genetics Wan Nor Ruddin, Wan Alif Afiq Ismail, Hamizah Mohd Nor, Nurul Yaqin Kaderi, Mohd Arifin Muda, Siti Mariam Daud, Normadiah Zainuddin, Norafiza Specific microRNAs among milk siblings: an epigenetics approach towards understanding the basis of milk kinship |
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Milk kinship is an Islamic belief described as a relationship established when infants receive breast milk from non-biological mothers. This form of kinship is said to bear a very close resemblance to blood relation whereby the recipients’ infants are regarded as milk siblings to the biological
children of the breastfeeding mother. Any future marriage between these individuals is forbidden likewise between the recipient infant and the nursing mother herself as they are thought to have a form of consanguinity. The consanguinity formed by virtue of milk sharing might be due to the composition of human breast milk, especially milk microRNAs that are responsible for the epigenetic modulation of gene expression. miRNAs can regulate gene expression by modulating genome-wide epigenetic status of genes, and similarly-shared genes might be the basis that has led
to milk kinship formation. Thus, the objective of the present study is to identify potential lactationspecific miRNAs that are similarly shared among milk siblings and their nursing mothers. The
study began with molecular extraction of milk RNA from the nursing mothers and cell-free plasma RNA from all milk siblings and their nursing mothers. The RNAs extracted from both sample types were further analyzed using NanoString nCounter® miRNA Panel Analysis (NanoString Technologies, Seattle, WA) to measure the abundance of individual miRNAs biomarkers present within the samples. This study is expected to provide scientific explanation that could divulge the secrets behind milk kinship establishment with thorough presentation on the lactation-specific miRNAs shared between milk siblings. Hence, the way for future research would be paved, making the development of milk kinship identification tool possible. |
format |
Article |
author |
Wan Nor Ruddin, Wan Alif Afiq Ismail, Hamizah Mohd Nor, Nurul Yaqin Kaderi, Mohd Arifin Muda, Siti Mariam Daud, Normadiah Zainuddin, Norafiza |
author_facet |
Wan Nor Ruddin, Wan Alif Afiq Ismail, Hamizah Mohd Nor, Nurul Yaqin Kaderi, Mohd Arifin Muda, Siti Mariam Daud, Normadiah Zainuddin, Norafiza |
author_sort |
Wan Nor Ruddin, Wan Alif Afiq |
title |
Specific microRNAs among milk siblings: an epigenetics
approach towards understanding the basis of milk kinship |
title_short |
Specific microRNAs among milk siblings: an epigenetics
approach towards understanding the basis of milk kinship |
title_full |
Specific microRNAs among milk siblings: an epigenetics
approach towards understanding the basis of milk kinship |
title_fullStr |
Specific microRNAs among milk siblings: an epigenetics
approach towards understanding the basis of milk kinship |
title_full_unstemmed |
Specific microRNAs among milk siblings: an epigenetics
approach towards understanding the basis of milk kinship |
title_sort |
specific micrornas among milk siblings: an epigenetics
approach towards understanding the basis of milk kinship |
publisher |
Universiti Putra Malaysia |
publishDate |
2023 |
url |
http://irep.iium.edu.my/106337/7/106337_Specific%20microRNAs%20Among%20Milk%20Siblings%20An%20Epigenetics.pdf http://irep.iium.edu.my/106337/ https://www.msmbb.my/index.php/archive-issues |
_version_ |
1802976963716972544 |
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13.18916 |