Agreement between TST and QuantiFERON-TB gold plus in diagnosing latent tuberculosis infection among exposed health care workers at a Malaysian teaching hospital
Incidence rates of tuberculosis (TB) infection among health care workers (HCWs) were always higher compared to the general population. The tuberculin skin test (TST), which was used to screen tuberculosis contact among HCWs has low specificity due to cross reaction with Bacille Calmette-Guerin (B...
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my.iium.irep.1060182023-08-22T01:23:27Z http://irep.iium.edu.my/106018/ Agreement between TST and QuantiFERON-TB gold plus in diagnosing latent tuberculosis infection among exposed health care workers at a Malaysian teaching hospital Meor Jamaludin, Wan Husna Barakah Sulong, Anita Abdul Samat, Muttaqillah Najihan Salleh, Sharifah Azura Ban, Andrea Yu Lin RA Public aspects of medicine RA643 Communicable Diseases and Public Health RC582 Specialities of Internal Medicine- Immunologic Diseases RC731 Specialties of Internal Medicine-Diseases of The Respiratory System Incidence rates of tuberculosis (TB) infection among health care workers (HCWs) were always higher compared to the general population. The tuberculin skin test (TST), which was used to screen tuberculosis contact among HCWs has low specificity due to cross reaction with Bacille Calmette-Guerin (BCG) vaccination or nontuberculosis mycobacterium infection. QuantiFERON-TB Gold Plus (QFT-Plus) offered higher specificity since it used specific antigens to stimulate the production of interferon-gamma in the serum. QFT-Plus could help narrow down the treatment group for latent tuberculosis infection among HCWs. To determine the agreement between TST and QFT-Plus in diagnosing latent tuberculosis infection among exposed health care workers in Hospital Canselor Tuanku Muhriz. Between January and December 2020, 417 HCWs were screened for TB close contact, 157 had positive TST and 260 had negative TST results. HCWs from both TST groups were selected using a convenient sampling method, and QFT-Plus testing was performed on 107 consented HCWs. From 107 consented HCWs, 21 (19.6%) had positive QFT-Plus. Among the positive QFT-Plus participants, 14 (66.7%) had positive TST, and 7 (33.3%) had negative TST. Meanwhile, among 86 (80.4%) HCWs had negative QFT-Plus, 35 (40.7%) had positive TST, and 51 (59.3%) had negative TST. There was poor agreement between the tests (kappa = 0.163). Poor agreement between TST and QFT-Plus in diagnosing latent tuberculosis infection among exposed HCWs. Malaysian Public Health Physicians’ Association 2022-11-18 Article PeerReviewed application/pdf en http://irep.iium.edu.my/106018/1/106018_Agreement%20between%20TST%20and%20QuantiFERON-TB.pdf Meor Jamaludin, Wan Husna Barakah and Sulong, Anita and Abdul Samat, Muttaqillah Najihan and Salleh, Sharifah Azura and Ban, Andrea Yu Lin (2022) Agreement between TST and QuantiFERON-TB gold plus in diagnosing latent tuberculosis infection among exposed health care workers at a Malaysian teaching hospital. Malaysian Journal of Public Health Medicine, 22 (Suppl. 2). p. 136. ISSN 1675-0306 E-ISSN 2590-3829 https://mjphm.org/index.php/mjphm/article/view/1947 |
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RA Public aspects of medicine RA643 Communicable Diseases and Public Health RC582 Specialities of Internal Medicine- Immunologic Diseases RC731 Specialties of Internal Medicine-Diseases of The Respiratory System Meor Jamaludin, Wan Husna Barakah Sulong, Anita Abdul Samat, Muttaqillah Najihan Salleh, Sharifah Azura Ban, Andrea Yu Lin Agreement between TST and QuantiFERON-TB gold plus in diagnosing latent tuberculosis infection among exposed health care workers at a Malaysian teaching hospital |
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Incidence rates of tuberculosis (TB) infection among health care workers (HCWs)
were always higher compared to the general population. The tuberculin skin test
(TST), which was used to screen tuberculosis contact among HCWs has low specificity
due to cross reaction with Bacille Calmette-Guerin (BCG) vaccination or nontuberculosis mycobacterium infection. QuantiFERON-TB Gold Plus (QFT-Plus) offered
higher specificity since it used specific antigens to stimulate the production of
interferon-gamma in the serum. QFT-Plus could help narrow down the treatment
group for latent tuberculosis infection among HCWs. To determine the agreement
between TST and QFT-Plus in diagnosing latent tuberculosis infection among exposed
health care workers in Hospital Canselor Tuanku Muhriz. Between January and
December 2020, 417 HCWs were screened for TB close contact, 157 had positive TST
and 260 had negative TST results. HCWs from both TST groups were selected using
a convenient sampling method, and QFT-Plus testing was performed on 107
consented HCWs. From 107 consented HCWs, 21 (19.6%) had positive QFT-Plus.
Among the positive QFT-Plus participants, 14 (66.7%) had positive TST, and 7 (33.3%)
had negative TST. Meanwhile, among 86 (80.4%) HCWs had negative QFT-Plus, 35
(40.7%) had positive TST, and 51 (59.3%) had negative TST. There was poor
agreement between the tests (kappa = 0.163). Poor agreement between TST and
QFT-Plus in diagnosing latent tuberculosis infection among exposed HCWs. |
format |
Article |
author |
Meor Jamaludin, Wan Husna Barakah Sulong, Anita Abdul Samat, Muttaqillah Najihan Salleh, Sharifah Azura Ban, Andrea Yu Lin |
author_facet |
Meor Jamaludin, Wan Husna Barakah Sulong, Anita Abdul Samat, Muttaqillah Najihan Salleh, Sharifah Azura Ban, Andrea Yu Lin |
author_sort |
Meor Jamaludin, Wan Husna Barakah |
title |
Agreement between TST and QuantiFERON-TB gold plus in diagnosing latent tuberculosis infection among exposed health care workers at a Malaysian teaching hospital |
title_short |
Agreement between TST and QuantiFERON-TB gold plus in diagnosing latent tuberculosis infection among exposed health care workers at a Malaysian teaching hospital |
title_full |
Agreement between TST and QuantiFERON-TB gold plus in diagnosing latent tuberculosis infection among exposed health care workers at a Malaysian teaching hospital |
title_fullStr |
Agreement between TST and QuantiFERON-TB gold plus in diagnosing latent tuberculosis infection among exposed health care workers at a Malaysian teaching hospital |
title_full_unstemmed |
Agreement between TST and QuantiFERON-TB gold plus in diagnosing latent tuberculosis infection among exposed health care workers at a Malaysian teaching hospital |
title_sort |
agreement between tst and quantiferon-tb gold plus in diagnosing latent tuberculosis infection among exposed health care workers at a malaysian teaching hospital |
publisher |
Malaysian Public Health Physicians’ Association |
publishDate |
2022 |
url |
http://irep.iium.edu.my/106018/1/106018_Agreement%20between%20TST%20and%20QuantiFERON-TB.pdf http://irep.iium.edu.my/106018/ https://mjphm.org/index.php/mjphm/article/view/1947 |
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13.160551 |