Reactive oxygen species and antioxidant system in selected skin disorders
The skin has a solid protective system that includes the stratum corneum as the primary barrier and a complete antioxidant defence system to maintain the skin’s normal redox homeostasis. The epidermal and dermal cells are continuously exposed to physiological levels of reactive oxygen species...
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| Format: | Article |
| Language: | English English |
| Published: |
Penerbit Universiti Sains Malaysia
2023
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/104338/2/104338_Reactive%20oxygen%20species%20and%20antioxidant%20system.pdf http://irep.iium.edu.my/104338/3/104338_Reactive%20oxygen%20species%20and%20antioxidant%20system_SCOPUS.pdf http://irep.iium.edu.my/104338/ http://www.mjms.usm.my/current.html |
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| Summary: | The skin has a solid protective system that includes the stratum corneum as the
primary barrier and a complete antioxidant defence system to maintain the skin’s normal redox
homeostasis. The epidermal and dermal cells are continuously exposed to physiological levels
of reactive oxygen species (ROS) originating from cellular metabolic activities. Environmental
insults, such as ultraviolet (UV) rays and air pollutants, also generate ROS that can contribute to
structural damage of the skin. The antioxidant defence system ensures that the ROS level remains
within the safe limit. In certain skin disorders, oxidative stress plays an important role, and
there is an established interplay between oxidative stress and inflammation in the development
of the condition. Lower levels of skin antioxidants indicate that oxidative stress may mediate the
pathogenesis of the disorder. Accordingly, the total antioxidant level was also found to be lower in
individuals with skin disorders in individuals with normal skin conditions. This review attempts
to summarise the skin oxidant sources and antioxidant system. In addition, both skin and total
antioxidant status of individuals with psoriasis, acne vulgaris, vitiligo and atopic dermatitis (AD),
as well as their associations with the progression of these disorders will be reviewed. |
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