Neuroprotective effect of phospholipase A2 from Malaysian Naja Sumatrana venom against H2O2-induced cell damage and apoptosis

• Main Authors: Abdullah, Nur Atiqah Haizum, Sainik, Nur Qisya Afifah Veronica, Esa, Ezalia, Muhamad Hendri, Nur Afrina, Ahmad Rusmili, Muhamad Rusdi, Hodgson, Wayne C., Shaikh, Mohd Farooq, Othman, Iekhsan
• Format: Article
• Language: English; English
• Published: Frontiers Media S.A. 2022
• Subjects: RM300 Drugs and their action; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/103691/3/103691_Neuroprotective%20effect%20of%20phospholipase%20A2_SCOPUS.pdf; http://irep.iium.edu.my/103691/4/103691_Neuroprotective%20effect%20of%20phospholipase%20A2.pdf; http://irep.iium.edu.my/103691/; https://www.frontiersin.org/articles/10.3389/fphar.2022.935418/pdf; https://doi.org/10.3389/fphar.2022.935418

Oxidative stress is one of the factors involved in the pathogenesis of several neurodegenerative diseases. It has been reported that a secretory phospholipase A2 known as A2-EPTX-NSm1a has lower cytotoxicity in neuronal cells compared to its crude Naja sumatrana venom. In this study, A2-EPTX-NSm1a w...