Co-processed excipients: a revisit of its development in the past two decades; a review
A pharmaceutical excipient is a substance acts as a carrier incorporates active pharmaceutical ingredients. Excipient selection focuses on desirable characteristics of excipients. Limitations of using excipients which affect the characteristics of the granules and tablets. Co-processed excipients a...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Wolters Kluwer Health
2022
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/102355/7/102355_Co-processed%20excipients%20%20a%20revisit_SCOPUS.pdf http://irep.iium.edu.my/102355/8/102355_Co-processed%20excipients%20%20a%20revisit.pdf http://irep.iium.edu.my/102355/ https://www.pnrjournal.com/index.php/home/article/download/1686/1440/2034 |
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| Summary: | A pharmaceutical excipient is a substance acts as a carrier incorporates active pharmaceutical ingredients. Excipient selection focuses on desirable characteristics of excipients. Limitations of using excipients which affect the characteristics of the granules and tablets. Co-processed excipients are produced by integrating one excipient into the other excipient at particle level. Such combination of two or more pharmacopeial or non-pharmacopeial excipients does not involve chemical reaction and only involve physical properties changes which is not possible by simple physical mixing. The introduced multicomponent-based excipients for formulation to obtain better features and tableting properties. The objectives of this revisit to discuss the development of co-processed excipients in the past two decades. This review summarizes the advantages of co-processed excipient, the manufacturing process, compilation of co-processed excipients in the literature, limitations, evaluation methods and future development of co-processed excipient. Co-processed excipients will undoubtedly attract attention from academia and pharmaceutical industry as more newer combinations of excipients and newer ways of co-processing become available Besides, rather using numerous excipients in formulation, it allows for the development and usage of single multifunctional excipients. |
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