Investigation of fluid flow system performance for biosensor application

• Main Authors: Muhammad Atan, Muhammad Khairul Faisal, Ab. Rahim, Rosminazuin, Nordin, Anis Nurashikin, Gunawan, Teddy Surya, Mohd Zain, Zainiharyati
• Format: Conference or Workshop Item
• Language: English; English; English
• Published: IEEE 2022
• Subjects: TK7885 Computer engineering
• Online Access: http://irep.iium.edu.my/101861/7/101861_Investigation%20of%20Fluid%20Flow%20System%20Performance%20Biosensor%20Application.pdf; http://irep.iium.edu.my/101861/13/101861_Investigation%20of%20fluid%20flow%20system%20performance%20for%20biosensor%20application_SCOPUS.png; http://irep.iium.edu.my/101861/1/KhairulMicrofluidicv4PDFexpress.pdf; http://irep.iium.edu.my/101861/; https://icsima.ieeemy-ims.org/22/program-schedule/; https://doi.org/10.1109/ICSIMA55652.2022.9929102

Electrochemical biosensors are advantageous for in-situ sensing applications measurements because of their low detection limit, good selectivity, minimum calibration requirement, and, most importantly, inexpensive cost. Nevertheless, integrated readout circuits for biosensing applications are typically cumbersome, costly, and not maintenance-free. Numerous studies have been conducted on electrochemical biosensor systems with portable readout circuits, specifically on potentiostat for diverse in-situ sensing applications. High-quality microfluidic packaging is required to build this portable sensor device. Before samples can be measured for biosensing applications, notably loop-mediated isothermal amplification (LAMP), they must undergo further treatments and heating. Therefore, in this paper, we have developed a portable biosensor application system consisting of sensor packaging, fluid flow, and a heater that can be used in the field without requiring laboratory or specialist equipment. The sensor packaging is 3D printed, and a fluid leakage test validates its performance. Two types of heaters are utilized for the heating system and compared. This portable biosensor device can be utilized for various in-situ electrochemical biosensing applications, including Covid-19 sensing, ions detection in saltwater, and heavy metals detection in water pollution.