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HYALURONAN-MEDIATED TARGETED DRUG-DELIVERY: SYNTHESIS, CHARACTERIZATION AND THE EFFECTS ON APOPTOTIC AND CELL SURVIVAL BIOMARKERS

In this study, paclitaxel (PTX) entrapped hyaluronic acid (HA) cross-linked nanoparticles (NPs) were synthesized for targeted delivery to cancer cells. The morphological characterization carried out by FESEM and TEM, showed that the NPs were spherical in shape, with sizes ranging from 20-100 nm....

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Main Author: CHAUDHRY, GUL-E-SABA
Format: Thesis
Language:English
Published: 2013
Subjects:
TP Chemical technology
Online Access:http://utpedia.utp.edu.my/22463/1/207CFE~1.PDF
http://utpedia.utp.edu.my/22463/
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spelling my-utp-utpedia.224632022-02-11T06:32:03Z http://utpedia.utp.edu.my/22463/ HYALURONAN-MEDIATED TARGETED DRUG-DELIVERY: SYNTHESIS, CHARACTERIZATION AND THE EFFECTS ON APOPTOTIC AND CELL SURVIVAL BIOMARKERS CHAUDHRY, GUL-E-SABA TP Chemical technology In this study, paclitaxel (PTX) entrapped hyaluronic acid (HA) cross-linked nanoparticles (NPs) were synthesized for targeted delivery to cancer cells. The morphological characterization carried out by FESEM and TEM, showed that the NPs were spherical in shape, with sizes ranging from 20-100 nm. The cross-linked HA polymers with entrapped PTX was confirmed by FTIR analysis and the characteristic peaks of PTX were observed at 1700 and 1736cm ·I. HA entrapment maintained the crystalline nature of the PTX molecule as suggested by XRD analysis. Modeling of release kinetics showed that PTX was released in a biphasic manner, with initial burst release of 60-70%, followed by a slow and uniform release. 2013-05 Thesis NonPeerReviewed application/pdf en http://utpedia.utp.edu.my/22463/1/207CFE~1.PDF CHAUDHRY, GUL-E-SABA (2013) HYALURONAN-MEDIATED TARGETED DRUG-DELIVERY: SYNTHESIS, CHARACTERIZATION AND THE EFFECTS ON APOPTOTIC AND CELL SURVIVAL BIOMARKERS. PhD thesis, Universiti Teknologi PETRONAS.
institution Universiti Teknologi Petronas
building UTP Resource Centre
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Teknologi Petronas
content_source UTP Electronic and Digitized Intellectual Asset
url_provider http://utpedia.utp.edu.my/
language English
topic TP Chemical technology
spellingShingle TP Chemical technology
CHAUDHRY, GUL-E-SABA
HYALURONAN-MEDIATED TARGETED DRUG-DELIVERY: SYNTHESIS, CHARACTERIZATION AND THE EFFECTS ON APOPTOTIC AND CELL SURVIVAL BIOMARKERS
description In this study, paclitaxel (PTX) entrapped hyaluronic acid (HA) cross-linked nanoparticles (NPs) were synthesized for targeted delivery to cancer cells. The morphological characterization carried out by FESEM and TEM, showed that the NPs were spherical in shape, with sizes ranging from 20-100 nm. The cross-linked HA polymers with entrapped PTX was confirmed by FTIR analysis and the characteristic peaks of PTX were observed at 1700 and 1736cm ·I. HA entrapment maintained the crystalline nature of the PTX molecule as suggested by XRD analysis. Modeling of release kinetics showed that PTX was released in a biphasic manner, with initial burst release of 60-70%, followed by a slow and uniform release.
format Thesis
author CHAUDHRY, GUL-E-SABA
author_facet CHAUDHRY, GUL-E-SABA
author_sort CHAUDHRY, GUL-E-SABA
title HYALURONAN-MEDIATED TARGETED DRUG-DELIVERY: SYNTHESIS, CHARACTERIZATION AND THE EFFECTS ON APOPTOTIC AND CELL SURVIVAL BIOMARKERS
title_short HYALURONAN-MEDIATED TARGETED DRUG-DELIVERY: SYNTHESIS, CHARACTERIZATION AND THE EFFECTS ON APOPTOTIC AND CELL SURVIVAL BIOMARKERS
title_full HYALURONAN-MEDIATED TARGETED DRUG-DELIVERY: SYNTHESIS, CHARACTERIZATION AND THE EFFECTS ON APOPTOTIC AND CELL SURVIVAL BIOMARKERS
title_fullStr HYALURONAN-MEDIATED TARGETED DRUG-DELIVERY: SYNTHESIS, CHARACTERIZATION AND THE EFFECTS ON APOPTOTIC AND CELL SURVIVAL BIOMARKERS
title_full_unstemmed HYALURONAN-MEDIATED TARGETED DRUG-DELIVERY: SYNTHESIS, CHARACTERIZATION AND THE EFFECTS ON APOPTOTIC AND CELL SURVIVAL BIOMARKERS
title_sort hyaluronan-mediated targeted drug-delivery: synthesis, characterization and the effects on apoptotic and cell survival biomarkers
publishDate 2013
url http://utpedia.utp.edu.my/22463/1/207CFE~1.PDF
http://utpedia.utp.edu.my/22463/
_version_ 1739832947892027392
score 13.188404

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