The association of adiponectin and leptin with objectively measured physical activity among adults: a brief review

• Main Authors: Lua, Pei Lin, Mohd Razif, Shahril, Nurnazahiah, A
• Format: Conference or Workshop Item
• Language: English
• Published: 2015
• Subjects: RA Public aspects of medicine; RA0421 Public health. Hygiene. Preventive Medicine
• Online Access: http://eprints.unisza.edu.my/693/1/FH03-FSK-15-04252.pdf; http://eprints.unisza.edu.my/693/

Strong evidence shows that physical inactivity increases the risk of many adverse health conditions, including major non-communicable diseases such as coronary heart disease, type 2 diabetes, and various cancers as well as shortens life expectancy. There are many mechanisms that may act through the effects of physical activity on health outcomes which resulting changes in circulating adiponectin and leptin. However studies on the association between self-reported physical activity level and adipokines found inconclusive results. Therefore this study aims to compile and analyse existing scientific evidence regarding the association between adiponectin and leptin with objectively measured physical activity among adults. Medline, PubMed, and Scopus databases were searched using specific keywords for articles related to the association between objectively measured physical activity on adiponectin and leptin. Only cross sectional studies among adults between year 2000 to 2015 were included. Studies that used subjective assessment of physical activity were excluded. A total of 1274 papers were retried from initial search. Only six studies met the inclusion criteria (n= 961). Five studies showed the effects of objectively measured physical activity on adiponectin and four studies on leptin. All four studies involving leptin showed a weak to moderate inverse association (r=0.213-0.443) and for adiponectin, three out of five studies showed a weak to moderate positive association (r=0.31-0.438) with objectively measured physical activity. Lower serum leptin and higher serum adiponectin concentration were associated with increased level of physical activity. As a conclusion, there is consistent evidence on the association between objectively measured physical activity and adipokines especially on leptin. More well-designed cross sectional studies using a larger sample size are needed to confirm these findings.