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IN VITRO ANTIVIRAL ACTIVITY OF ORTHOSIPHON STAMINEUS EXTRACT AGAINST DENGUE VIRUS TYPE 2

In this study, Orthosiphon stamineus aqueous leaves extract was tested against dengue virus type 2. Cytotoxicity screening against Vero cells using MTT assay showed that the CC50 values for extract is 5 mg/ml. The antiviral activity towards Dengue virus type 2 (DENV-2) was investigated by observi...

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Main Authors: Noor Zarina, Abd Wahab, Adiana, Ghazali, Mohd Khairul Amri, Kamarudin
Format: Article
Language:English
Published: 2018
Subjects:
QH301 Biology
Online Access:http://eprints.unisza.edu.my/6714/1/FH02-FSK-18-13446.pdf
http://eprints.unisza.edu.my/6714/
http://www.jfas.info/index.php/jfas/issue/view/47
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spelling my-unisza-ir.67142022-04-03T03:43:42Z http://eprints.unisza.edu.my/6714/ IN VITRO ANTIVIRAL ACTIVITY OF ORTHOSIPHON STAMINEUS EXTRACT AGAINST DENGUE VIRUS TYPE 2 Noor Zarina, Abd Wahab Adiana, Ghazali Mohd Khairul Amri, Kamarudin QH301 Biology In this study, Orthosiphon stamineus aqueous leaves extract was tested against dengue virus type 2. Cytotoxicity screening against Vero cells using MTT assay showed that the CC50 values for extract is 5 mg/ml. The antiviral activity towards Dengue virus type 2 (DENV-2) was investigated by observing the morphological changes, which were further confirmed the cellular viability evaluated by MTT technique. The selective indices (SI = CC50 / EC50) for the extract is 13. These results demonstrate that the extract prepared from O. stamineus possesses phytochemical compound that was non cytotoxic to the cell with potential antiviral activity. These species are good candidates for further activity-monitored fractionation to identify active principles. 2018-01 Article PeerReviewed text en http://eprints.unisza.edu.my/6714/1/FH02-FSK-18-13446.pdf Noor Zarina, Abd Wahab and Adiana, Ghazali and Mohd Khairul Amri, Kamarudin (2018) IN VITRO ANTIVIRAL ACTIVITY OF ORTHOSIPHON STAMINEUS EXTRACT AGAINST DENGUE VIRUS TYPE 2. Journal of Fundamental and Applied Sciences, 10 (1S). pp. 541-551. ISSN 1112-9867 http://www.jfas.info/index.php/jfas/issue/view/47
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
topic QH301 Biology
spellingShingle QH301 Biology
Noor Zarina, Abd Wahab
Adiana, Ghazali
Mohd Khairul Amri, Kamarudin
IN VITRO ANTIVIRAL ACTIVITY OF ORTHOSIPHON STAMINEUS EXTRACT AGAINST DENGUE VIRUS TYPE 2
description In this study, Orthosiphon stamineus aqueous leaves extract was tested against dengue virus type 2. Cytotoxicity screening against Vero cells using MTT assay showed that the CC50 values for extract is 5 mg/ml. The antiviral activity towards Dengue virus type 2 (DENV-2) was investigated by observing the morphological changes, which were further confirmed the cellular viability evaluated by MTT technique. The selective indices (SI = CC50 / EC50) for the extract is 13. These results demonstrate that the extract prepared from O. stamineus possesses phytochemical compound that was non cytotoxic to the cell with potential antiviral activity. These species are good candidates for further activity-monitored fractionation to identify active principles.
format Article
author Noor Zarina, Abd Wahab
Adiana, Ghazali
Mohd Khairul Amri, Kamarudin
author_facet Noor Zarina, Abd Wahab
Adiana, Ghazali
Mohd Khairul Amri, Kamarudin
author_sort Noor Zarina, Abd Wahab
title IN VITRO ANTIVIRAL ACTIVITY OF ORTHOSIPHON STAMINEUS EXTRACT AGAINST DENGUE VIRUS TYPE 2
title_short IN VITRO ANTIVIRAL ACTIVITY OF ORTHOSIPHON STAMINEUS EXTRACT AGAINST DENGUE VIRUS TYPE 2
title_full IN VITRO ANTIVIRAL ACTIVITY OF ORTHOSIPHON STAMINEUS EXTRACT AGAINST DENGUE VIRUS TYPE 2
title_fullStr IN VITRO ANTIVIRAL ACTIVITY OF ORTHOSIPHON STAMINEUS EXTRACT AGAINST DENGUE VIRUS TYPE 2
title_full_unstemmed IN VITRO ANTIVIRAL ACTIVITY OF ORTHOSIPHON STAMINEUS EXTRACT AGAINST DENGUE VIRUS TYPE 2
title_sort in vitro antiviral activity of orthosiphon stamineus extract against dengue virus type 2
publishDate 2018
url http://eprints.unisza.edu.my/6714/1/FH02-FSK-18-13446.pdf
http://eprints.unisza.edu.my/6714/
http://www.jfas.info/index.php/jfas/issue/view/47
_version_ 1729708882628968448
score 13.213112

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