Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death
Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked...
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my-unisza-ir.65152022-09-13T04:44:33Z http://eprints.unisza.edu.my/6515/ Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death Abd Manaf, Ali Kannan Badri, Narayanan Barry James, Barclay QH301 Biology Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of pro-survival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of pro-apoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis. Oxford University Press 2015 Article PeerReviewed image en http://eprints.unisza.edu.my/6515/1/FH02-FBIM-15-03645.jpg image en http://eprints.unisza.edu.my/6515/2/FH02-FBIM-15-03767.jpg Abd Manaf, Ali and Kannan Badri, Narayanan and Barry James, Barclay (2015) Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death. Carcinogenesis, 36. pp. 89-110. ISSN 01433334 |
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QH301 Biology Abd Manaf, Ali Kannan Badri, Narayanan Barry James, Barclay Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
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Cell death is a process of dying within biological cells that are ceasing to function. This process is essential in regulating organism development, tissue homeostasis, and to eliminate cells in the body that are irreparably damaged. In general, dysfunction in normal cellular death is tightly linked to cancer progression. Specifically, the up-regulation of pro-survival factors, including oncogenic factors and antiapoptotic signaling pathways, and the down-regulation of pro-apoptotic factors, including tumor suppressive factors, confers resistance to cell death in tumor cells, which supports the emergence of a fully immortalized cellular phenotype. This review considers the potential relevance of ubiquitous environmental chemical exposures that have been shown to disrupt key pathways and mechanisms associated with this sort of dysfunction. Specifically, bisphenol A, chlorothalonil, dibutyl phthalate, dichlorvos, lindane, linuron, methoxychlor and oxyfluorfen are discussed as prototypical chemical disruptors; as their effects relate to resistance to cell death, as constituents within environmental mixtures and as potential contributors to environmental carcinogenesis. |
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Article |
author |
Abd Manaf, Ali Kannan Badri, Narayanan Barry James, Barclay |
author_facet |
Abd Manaf, Ali Kannan Badri, Narayanan Barry James, Barclay |
author_sort |
Abd Manaf, Ali |
title |
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
title_short |
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
title_full |
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
title_fullStr |
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
title_full_unstemmed |
Disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
title_sort |
disruptive environmental chemicals and cellular mechanisms that confer resistance to cell death |
publisher |
Oxford University Press |
publishDate |
2015 |
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http://eprints.unisza.edu.my/6515/1/FH02-FBIM-15-03645.jpg http://eprints.unisza.edu.my/6515/2/FH02-FBIM-15-03767.jpg http://eprints.unisza.edu.my/6515/ |
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1744358556063236096 |
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13.18916 |