Computational Characterization of the Promoter Region of SMN2 (Survival of Motor Neuron) Gene

• Main Authors: Atif, Amin Baig, Ahmad Zubaidi, A.latif, Nordin, Simbak, Tengku Muhammad Ariff, Raja Hussin
• Format: Article
• Language: English
• Published: 2018
• Subjects: R Medicine (General)
• Online Access: http://eprints.unisza.edu.my/5696/1/FH02-FP-19-24396.pdf; http://eprints.unisza.edu.my/5696/

SMN (Survival of Motor Neuron) has two isotypes; SMN1 and SMN2 encoding for FL-SMN protein (functional SMN) and Δ7SMN protein (non functional). The lack of SMN1 produce spinal muscular atrophy (SMA) and the increasing gene dosage of SMN2 have been shown to decrease the severity of the SMA. The core...