Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett
: One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobilo...
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my-unisza-ir.24512021-08-21T08:20:10Z http://eprints.unisza.edu.my/2451/ Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett Abd Manaf, Ali Najihah, Mohd. Hashim Mawardi, Rahmani Gwendoline, Cheng Lian Ee S Agriculture (General) : One of the most promising plants in biological screening test results of thirteen Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical investigation of powdered dried bark of the plant has led to the isolation and identification of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant, antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1) exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of 2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid, α-tocopherol and quercetin, The compound also exhibited antibacterial activity against methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two xanthones were found to be inactive. For the tyrosinase inhibitory activity, again compound (1) displayed strong activity comparable with the standard kojic acid 2012 Article NonPeerReviewed text en http://eprints.unisza.edu.my/2451/1/FH02-FPBSM-14-00519.pdf image en http://eprints.unisza.edu.my/2451/2/FH02-FPBSM-14-01149.jpg Abd Manaf, Ali and Najihah, Mohd. Hashim and Mawardi, Rahmani and Gwendoline, Cheng Lian Ee (2012) Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett. Molecules. pp. 6071-6082. ISSN 1420-3049 |
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S Agriculture (General) Abd Manaf, Ali Najihah, Mohd. Hashim Mawardi, Rahmani Gwendoline, Cheng Lian Ee Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett |
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: One of the most promising plants in biological screening test results of thirteen
Artocarpus species was Artocarpus obtusus FM Jarrett and detailed phytochemical
investigation of powdered dried bark of the plant has led to the isolation and identification
of three xanthones; pyranocycloartobiloxanthone A (1), dihydroartoindonesianin C (2) and
pyranocycloartobiloxanthone B (3). These compounds were screened for antioxidant,
antimicrobial and tyrosinase inhibitory activities. Pyranocycloartobiloxanthone A (1)
exhibited a strong free radical scavenger towards DPPH free radicals with IC50 value of
2 µg/mL with prominent discoloration observed in comparison with standard ascorbic acid,
α-tocopherol and quercetin, The compound also exhibited antibacterial activity against
methicillin resistant Staphylococcus aureus (ATCC3359) and Bacillus subtilis (clinically
isolated) with inhibition zone of 20 and 12 mm, respectively. However the other two
xanthones were found to be inactive. For the tyrosinase inhibitory activity, again
compound (1) displayed strong activity comparable with the standard kojic acid |
format |
Article |
author |
Abd Manaf, Ali Najihah, Mohd. Hashim Mawardi, Rahmani Gwendoline, Cheng Lian Ee |
author_facet |
Abd Manaf, Ali Najihah, Mohd. Hashim Mawardi, Rahmani Gwendoline, Cheng Lian Ee |
author_sort |
Abd Manaf, Ali |
title |
Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett |
title_short |
Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett |
title_full |
Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett |
title_fullStr |
Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett |
title_full_unstemmed |
Antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus F.M. Jarrett |
title_sort |
antioxidant, antimicrobial and tyrosinase inhibitory activities of xanthones isolated from artocarpus obtusus f.m. jarrett |
publishDate |
2012 |
url |
http://eprints.unisza.edu.my/2451/1/FH02-FPBSM-14-00519.pdf http://eprints.unisza.edu.my/2451/2/FH02-FPBSM-14-01149.jpg http://eprints.unisza.edu.my/2451/ |
_version_ |
1709673160751710208 |
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13.160551 |