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Immunomodulatory effect of Rhaphidophora korthalsii on mice splenocyte, thymocyte and bone marrow cell proliferation and cytokine expression

Rhaphidophora korthalsii methanol extract was previously found as a potential in vitro immunomodulating agent. In this study, the in vitro immunomodulatory activity of R. korthalsii methanol extract on mice splenocyte were quantified through evaluating T/NK cell population. cytokine expression (IL-2...

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Main Author: Abd Manaf, Ali
Format: Article
Language:English
Published: 2011
Subjects:
S Agriculture (General)
T Technology (General)
Online Access:http://eprints.unisza.edu.my/2143/1/FH02-FPBSM-14-00427.png
http://eprints.unisza.edu.my/2143/
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spelling my-unisza-ir.21432021-08-15T03:03:19Z http://eprints.unisza.edu.my/2143/ Immunomodulatory effect of Rhaphidophora korthalsii on mice splenocyte, thymocyte and bone marrow cell proliferation and cytokine expression Abd Manaf, Ali S Agriculture (General) T Technology (General) Rhaphidophora korthalsii methanol extract was previously found as a potential in vitro immunomodulating agent. In this study, the in vitro immunomodulatory activity of R. korthalsii methanol extract on mice splenocyte were quantified through evaluating T/NK cell population. cytokine expression (IL-2 and IFN-y) and cytotoxicity against Yac-1 cell In vitro MTT proliferation study showed that R. korthalsii methanol extract stimulate significant proliferation of splenocyte. thymocyte and bone marrow cell at 25 pg/ml after 72 h incubation as compared to rIL-2. Besides. 25 lig/ma of extract also enhanced T-helper 1 cytokine (IL-2 and IFN-y) secretion. natural killer cell (NK1.1 *CO3-) population and cytotoxicity against natural killer sensitive Yac-1 leukemic cell line. It was concluded that R. korthalsii methanol extract is a potential immunomodulator agent that could activate the natural killer cell. 0 2011 Academic Journals_ Author keywords 2011 Article NonPeerReviewed image en http://eprints.unisza.edu.my/2143/1/FH02-FPBSM-14-00427.png Abd Manaf, Ali (2011) Immunomodulatory effect of Rhaphidophora korthalsii on mice splenocyte, thymocyte and bone marrow cell proliferation and cytokine expression. African journal of biotechnology. pp. 10744-10751. ISSN 16845315
institution Universiti Sultan Zainal Abidin
building UNISZA Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Sultan Zainal Abidin
content_source UNISZA Institutional Repository
url_provider https://eprints.unisza.edu.my/
language English
topic S Agriculture (General)
T Technology (General)
spellingShingle S Agriculture (General)
T Technology (General)
Abd Manaf, Ali
Immunomodulatory effect of Rhaphidophora korthalsii on mice splenocyte, thymocyte and bone marrow cell proliferation and cytokine expression
description Rhaphidophora korthalsii methanol extract was previously found as a potential in vitro immunomodulating agent. In this study, the in vitro immunomodulatory activity of R. korthalsii methanol extract on mice splenocyte were quantified through evaluating T/NK cell population. cytokine expression (IL-2 and IFN-y) and cytotoxicity against Yac-1 cell In vitro MTT proliferation study showed that R. korthalsii methanol extract stimulate significant proliferation of splenocyte. thymocyte and bone marrow cell at 25 pg/ml after 72 h incubation as compared to rIL-2. Besides. 25 lig/ma of extract also enhanced T-helper 1 cytokine (IL-2 and IFN-y) secretion. natural killer cell (NK1.1 *CO3-) population and cytotoxicity against natural killer sensitive Yac-1 leukemic cell line. It was concluded that R. korthalsii methanol extract is a potential immunomodulator agent that could activate the natural killer cell. 0 2011 Academic Journals_ Author keywords
format Article
author Abd Manaf, Ali
author_facet Abd Manaf, Ali
author_sort Abd Manaf, Ali
title Immunomodulatory effect of Rhaphidophora korthalsii on mice splenocyte, thymocyte and bone marrow cell proliferation and cytokine expression
title_short Immunomodulatory effect of Rhaphidophora korthalsii on mice splenocyte, thymocyte and bone marrow cell proliferation and cytokine expression
title_full Immunomodulatory effect of Rhaphidophora korthalsii on mice splenocyte, thymocyte and bone marrow cell proliferation and cytokine expression
title_fullStr Immunomodulatory effect of Rhaphidophora korthalsii on mice splenocyte, thymocyte and bone marrow cell proliferation and cytokine expression
title_full_unstemmed Immunomodulatory effect of Rhaphidophora korthalsii on mice splenocyte, thymocyte and bone marrow cell proliferation and cytokine expression
title_sort immunomodulatory effect of rhaphidophora korthalsii on mice splenocyte, thymocyte and bone marrow cell proliferation and cytokine expression
publishDate 2011
url http://eprints.unisza.edu.my/2143/1/FH02-FPBSM-14-00427.png
http://eprints.unisza.edu.my/2143/
_version_ 1709673143397777408
score 13.209306

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