Matrine enhances the inhibitory effect of 5-FU on SW480 cells in vitro and in vivo

• Main Authors: Xu, Hui Zhang, Lei, Liang, Xiao, Yan Wang, Li, Zhang, Yan, Xin Zheng, Hong, Zhu Deng, Xin, Rong Wu
• Format: Article
• Language: English
• Published: Universiti Kebangsaan Malaysia 2016
• Online Access: http://journalarticle.ukm.my/9575/1/13_Lei_Liang.pdf; http://journalarticle.ukm.my/9575/; http://www.ukm.my/jsm/malay_journals/jilid45bil1_2016/KandunganJilid45Bil1_2016.htm

We investigated the antitumor effects of the combination of matrine-a purified alkaloid extracted from Sophora flavescence-and 5-fluorouracil (5-FU) on SW480 cells. This combination inhibited the growth of SW480 cells in a synergistic or additive manner by disrupting their progression through the ce...