Kesan in vitro rilmenidine ke atas rembesan insulin
This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak...
Saved in:
Main Authors: | , , |
---|---|
Format: | Article |
Language: | English |
Published: |
penerbit ukm
2003
|
Online Access: | http://journalarticle.ukm.my/948/1/jurnal4.pdf http://journalarticle.ukm.my/948/ http://www.fskb.ukm.my/fskbold/jurnal |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
id |
my-ukm.journal.948 |
---|---|
record_format |
eprints |
spelling |
my-ukm.journal.9482016-12-14T06:28:23Z http://journalarticle.ukm.my/948/ Kesan in vitro rilmenidine ke atas rembesan insulin Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations. penerbit ukm 2003-07 Article PeerReviewed application/pdf en http://journalarticle.ukm.my/948/1/jurnal4.pdf Rosnani Hashim, and Tariq Abdul Razak, and Suhaimi Hashim, (2003) Kesan in vitro rilmenidine ke atas rembesan insulin. Jurnal Sains Kesihatan Malaysia, 1 . pp. 1-7. ISSN 1675-8161 http://www.fskb.ukm.my/fskbold/jurnal |
institution |
Universiti Kebangsaan Malaysia |
building |
Perpustakaan Tun Sri Lanang Library |
collection |
Institutional Repository |
continent |
Asia |
country |
Malaysia |
content_provider |
Universiti Kebangsaan Malaysia |
content_source |
UKM Journal Article Repository |
url_provider |
http://journalarticle.ukm.my/ |
language |
English |
description |
This study was carried out to determine the in vitro effect of a new antihypertensive drug, Rilmenidine, on insulin secretion. The direct effect of Rilmenidine on glucose-induced insulin secretion was studied using isolated rat pancreas. The concentrations of Rilmenidine used were based on the peak plasma concentration achieved with an oral dose of 1 mg. T a low concentration, Rilmenidine (0.35 ng/ml) significantly stimulated insulin secretion (p‹0.01). However, Rilmenidine showed a significantly weak inhibition (p< 0.05) at 3.5 ng/ml and a strong inhibitin at a higher concentration (35.0 ng/ml). The result showed that Rilmenidine exhibited significant stimulating and inhibitory effects on insulin secretion from the pancreas at different concentrations. |
format |
Article |
author |
Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, |
spellingShingle |
Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, Kesan in vitro rilmenidine ke atas rembesan insulin |
author_facet |
Rosnani Hashim, Tariq Abdul Razak, Suhaimi Hashim, |
author_sort |
Rosnani Hashim, |
title |
Kesan in vitro rilmenidine ke atas rembesan insulin |
title_short |
Kesan in vitro rilmenidine ke atas rembesan insulin |
title_full |
Kesan in vitro rilmenidine ke atas rembesan insulin |
title_fullStr |
Kesan in vitro rilmenidine ke atas rembesan insulin |
title_full_unstemmed |
Kesan in vitro rilmenidine ke atas rembesan insulin |
title_sort |
kesan in vitro rilmenidine ke atas rembesan insulin |
publisher |
penerbit ukm |
publishDate |
2003 |
url |
http://journalarticle.ukm.my/948/1/jurnal4.pdf http://journalarticle.ukm.my/948/ http://www.fskb.ukm.my/fskbold/jurnal |
_version_ |
1643734851238494208 |
score |
13.19449 |