Aloe emodin induces apoptosis in ER+-breast cancer cells; MCF-7 through IGF-1R signalling pathway

• Main Authors: Indah Mohd Amin,, Roziana Kamaludin,, Swee, Keong Yeap, Mohamad Rodi Isa,, Nik Mohd Mazuan Nik Mohd Rosdy,, Rosfaiizah Siran,, Siti Hamimah Sheikh Abdul Kadir,, Narimah Abdul Hamid Hasani,
• Format: Article
• Language: English
• Published: Universiti Kebangsaan Malaysia 2015
• Online Access: http://journalarticle.ukm.my/9043/1/09_Indah_Mohd_Amin.pdf; http://journalarticle.ukm.my/9043/; http://www.ukm.my/jsm/english_journals/vol44num8_2015/contentsVol44num8_2015.html

Two-third of breast cancer patients expressed estrogen receptors (ER)s and received endocrine treatment with established anti-estrogens such as tamoxifen. But the action and acquired resistance during treatment are largely unknown. In contrary, phytochemicals are more selective and less cytotoxic to...